Bupropion-Associated Premature Ejaculation

Kravos, Matej

doi:10.1055/s-0030-1249034

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…Anecdotal reports also mentioned cases of acquired PE following withdrawal of SSRI medication (e.g. citalopram) [34] or use of the norepinephrine and dopamine reuptake inhibitor bupropion [35].…”

Section: Pharmacological Factorsmentioning

confidence: 99%

Pathophysiology of Premature Ejaculation

Buvat¹

2011

The Journal of Sexual Medicine

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Introduction Although the characteristics of premature ejaculation (PE) are established, the exact aetiology is largely unknown. Genetic, neurobiological, pharmacological, psychological, urological and endocrine factors have all been proposed. In addition PE and erectile dysfunction are often co-morbid. Aim This article provides an overview of the proposed biological and psychological aetiologies of PE. Methods Review of the literature. Main Outcome Measures Current data on the pathophysiology of PE. Results This review shows that most of the proposed biological and psychological aetiologies of PE are not evidence-based and/or that attempts to confirm them have given conflicting results. There are good data to support roles for genetic and psychological factors, either causal, or secondary to PE for the latter, in lifelong PE. Conversely, more evidence-based data support the responsibility of opioid substance withdrawal, prostatic inflammation or hyperthyroidism in some cases of acquired PE, in addition to a probable role of psychological factors. Conclusions The determinants of PE are certainly complex and multifactorial, while each partner's reaction to the frustration caused by the sexual dysfunction may exacerbate or perpetuate it. It is important to understand, as far as possible, the aetiology in the individual patient to ensure appropriate assessment and treatment. It should be noted that identification of an aetiological factor does not necessarily mean the cause of the PE has been completely explained, and the patient may require a combination of treatment approaches.

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Section: Pharmacological Factorsmentioning

confidence: 99%

Pathophysiology of Premature Ejaculation

Buvat¹

2011

The Journal of Sexual Medicine

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“…The rationale for using bupropion in DE comes from the following observations: (I) it has been shown that chronic bupropion administration at high doses alters the function of the spinal generator for ejaculation (SGE) in rats (24); (II) bupropion produces concentration- dependent increases in the contractile response to nerve stimulation in the rat vas deferens and significantly increases the pressor response to noradrenaline suggesting facilitatory action of the ejaculatory reflex (25); (III) in vitro bupropion increases by eight-fold the NE potency in inducing contractions of the epididymal duct from untreated rats. The ability of bupropion to enhance epididymal duct contractions to NE is due to its action as a NE transporter blocker as bupropion did not change duct contraction to methoxamine (26); (IV) bupropion has been demonstrated to induce premature ejaculation in 46 years old man after the use of 150 mg bupropion per day for depression and premature ejaculation disappeared two weeks after stopping of bupropion (27,28); and (V) bupropion showed prosexual effects when compared with the other antidepressants and no patient taking bupropion complained of delayed orgasm (29). Most of the studies have noted that bupropion is not only as effective as other antidepressants but has the advantage of a lower impact on the sexual function.…”

Section: Bupropionmentioning

confidence: 99%

The drug treatment of delayed ejaculation

Abdel‐Hamid¹,

Elsaied²,

Mostafa³

2016

Transl. Androl. Urol.

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Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically .We also highlighted specific settings where drugs could be introduced to medical practice. Electronic databases were searched from 1966 to February 2016, including PubMed MEDLINE, EMBASE, EBCSO Academic Search Complete, Cochrane Systematic Reviews Database, and Google Scholar using key words; delayed ejaculation, retarded ejaculation, inhibited ejaculation, drugs, treatment, or pharmacology. To achieve the maximum sensitivity of the search strategy and to identify all studies, we combined “delayed ejaculation” as Medical Subject Headings (MeSH) terms or keywords with each of “testosterone” or “cabergoline” or “bupropion” or “amantadine” or “cyproheptadine” or “midodrine” or “imipramine” or “ephedrine” or “pseudoephedrine” or “yohimbine” or “buspirone” or “oxytocin” or “bethanechol” as MeSH terms or keywords. There are a number of drugs to treat patients with DE including: testosterone, cabergoline, bupropion, amantadine, cyproheptadine, midodrine, imipramine, ephedrine, pseudoephedrine, yohimbine, buspirone, oxytocin, and bethanechol. Although there are many pharmacological treatment options, the evidence is still limited to small trials, case series or case reports. Review of literature showed that evidence level 1 (Double blind randomized clinical trial) studies were performed with testosterone, oxytocin, buspirone or bethanechol treatment. It is concluded that successful drug treatment of DE is still in its infancy. The clinicians need to be aware of the pathogenesis of DE and the pharmacological basis underlying the use of different drugs to extend better care for these patients. Various drugs are available to address such problem, however their evidence of efficacy is still limited and their choice needs to be individualized to each specific case.

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Antidepressant drugs

Chan¹,

Mitchell²

2012

A Worldwide Yearly Survey of New Data in Adverse Drug Reactions and Interactions

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Bupropion-Associated Premature Ejaculation

Cited by 6 publications

References 10 publications

Pathophysiology of Premature Ejaculation

Pathophysiology of Premature Ejaculation

The drug treatment of delayed ejaculation

Antidepressant drugs

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