“…Chronic methadone exposure has also been linked to increased impulsivity, non-planning impulsivity, and lower cognitive flexibility compared to healthy controls [60]. Similarly, research has demonstrated that buprenorphine can impair higher cerebral functioning, though to a lesser extent than methadone [61]. As a result, when considering treatment options for healthcare professionals, opioid substitution therapy may not be advisable, due to the possibility of impaired cognitive functioning.…”