2013
DOI: 10.1016/j.jpba.2012.12.023
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Buprenorphine and norbuprenorphine quantification in human plasma by simple protein precipitation and ultra-high performance liquid chromatography tandem mass spectrometry

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Cited by 23 publications
(24 citation statements)
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“…When applying the optimized method, the estimated LoD and LoQ were lower than those reported for the original method [15]. The estimated LoQ is lower than the value reported by Luthi and colleagues (0.1 ng/mL) [19]. Similarly, the sensitivity of the optimized method appeared to be lower than the value obtained by Regina and Karash [20].…”
Section: Discussionmentioning
confidence: 55%
“…When applying the optimized method, the estimated LoD and LoQ were lower than those reported for the original method [15]. The estimated LoQ is lower than the value reported by Luthi and colleagues (0.1 ng/mL) [19]. Similarly, the sensitivity of the optimized method appeared to be lower than the value obtained by Regina and Karash [20].…”
Section: Discussionmentioning
confidence: 55%
“…With the following 10‐fold dilution using the mobile phase, the consistency of the sample and mobile phase was ensured so that the solvent evaporation and reconstitution process could be circumvented. Such simplification made the whole pretreatment procedure shorter than in many other previous studies (de Souza, Domingues, & Queiroz, ; Lüthi et al, ; Zheng, Wang, Hu, & Feng, ).…”
Section: Resultsmentioning
confidence: 95%
“…Although the widely used liquid–liquid extraction and solid‐phase extraction methods are highly specific, the intricate operating process and relatively long work‐up time make them difficult to introduce into daily clinical usage. In comparison, protein precipitation, which could also provide sufficient decontaminating efficiency, is simple and has been used for the purification of many psychotropic drugs (Lüthi, Blangy, Eap, & Ansermot, ). In the present study, after optimization, a mixture of acetonitrile and methanol (50:50 v /v) was used as the precipitating initiator to achieve the highest precipitation efficiency.…”
Section: Resultsmentioning
confidence: 99%
“…Methods for quantification of buprenorphine and one or more major metabolites in plasma and/or urine include immunoassay [22,23], gas chromatography with various detectors [2428], HPLC with single quadrupole or tandem quadrupole mass spectrometry [13,2935], and most recently UPLC methods with mass spectrometry [3640]. Various methods of sample preparation have also been described, including protein precipitation [40], liquid/liquid extraction [39], and solid-phase extraction [37,41,42].…”
Section: Introductionmentioning
confidence: 99%
“…Various methods of sample preparation have also been described, including protein precipitation [40], liquid/liquid extraction [39], and solid-phase extraction [37,41,42]. The most sensitive of the above assays generally have a lower limit of quantification of approximately 0.1 ng/mL for buprenorphine and 0.25 ng/mL for norbuprenorphine, and the glucuronide metabolites are often not analyzed.…”
Section: Introductionmentioning
confidence: 99%