Buprederm™, a New Transdermal Delivery System of Buprenorphine: Pharmacokinetic, Efficacy and Skin Irritancy Studies

Abstract

Buprederm was shown to be efficacious by achieving the effective buprenorphine concentration in the blood and brain sufficient to maintain an analgesic effect for 72 h, and was also shown to be safe following multiple applications.

Evaluation of buprenorphine hydrochloride Pluronic® gel formulation in male C57BL/6NCrl mice

“…Biodegradable synthetic hydrogels are continuously being evaluated in vitro and in vivo for use in drug and cell delivery 19–23,35,44–48 . Specific for buprenorphine, Graves, Freeman, and Mandal 25 created an in situ buprenorphine gel formulation and developed an in vitro method to evaluate its dissolution.…”

Improving the Antibacterial Property of Porcine Small Intestinal Submucosa by Nano-Silver Supplementation

“…Therefore the irritancy potential of NS-PSIS after single and repeated application was negligible according to the Draize dermal scoring criteria. 20 Meanwhile, all the 3 animals appeared active and healthy during period of skin irritancy test. There were no signs of gross toxicity, abnormal behavior or the other adverse pharmacologic effects observed.…”

“…Individual dose sites were scored according to the Draize' scoring system at 24, 48, and 72 hours after application. 20 In addition, the blood samples from the orbital veins on postoperative 1, 3, 5, 7, 15, and 30 days, and the liver, brain and kidney samples on postoperative 30 days were taken for the trace silver determination by FAAS.…”

Advances in Exotic Mammal Clinical Therapeutics

“…68 A transdermal hydrogel buprenorphine patch providing one-fifth of the human dose was found to provide human analgesic plasma concentrations in rabbits for 72 hours and was also found to be safe after multiple applications. 69 Although this patch is not yet commercially available, this new route of administration may be useful for longer durations of administration in the future for exotic mammal patients.…”