Bupleurum falcatum Prevents Depression and Anxiety-Like Behaviors in Rats Exposed to Repeated Restraint Stress

Lee, Bom Bi; Yun, Hye Yeon; Shim, In Sop; Lee, Hye Jung; Hahm, Dae Hyun

doi:10.4014/jmb.1110.10077

Cited by 35 publications

(24 citation statements)

References 38 publications

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“…However, the chemical constituents of CSGS related to its efficacy were still not clear, even though some constituents with antidepressant effect were reported from the single herbs of CSGS, such as saikosides (Chai-Hu) [24], total glycosides of paeonia (TGP, Bai-Shao) [25], and liquiritin (Gan-Cao) [26]. …”

Section: Discussionmentioning

confidence: 99%

Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San

Jia

Long

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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This study proposed a new strategy for uncovering the active chemical constituents of a traditional Chinese medicines (TCMs) formula, Chaihu-Shu-Gan-San (CSGS). Metabonomics and chemical profile were integrated in combination with the multivariate statistical analysis (MVA) to discover the chemical constituents which contribute to the antidepressant effect of CSGS. Based upon the difference between CSGS and QZ (CSGS without Zhi-Qiao) extracts in the chemical profiles and the regulations of metabolic disturbances induced by CUMS, synephrine, naringin, hesperidin, and neohesperidin were recognized as the active constituents of CSGS from Zhi-qiao responsible for those missing regulations of CSGS when Zhi-Qiao was subtracted from the whole formula. They participated in the regulations of the deviated metabolites 2–4, 10–14, and 22–25, involved in metabolic pathways of ketone bodies synthesis, phenylalanine, tyrosine and tryptophan biosynthesis, valine, aspartate, glutamate metabolism, and glycolysis/gluconeogenesis. Furthermore, the assay of MAO-A activity confirmed the potential antidepressant effect of naringin and its active sites on the MAO-A was inferred by molecular docking study. The integration of metabonomics and chemical profile was proved to be a useful strategy for uncovering what the active chemical constituents in TCM formula are and how they make contributions for the efficacy of the formula.

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Section: Discussionmentioning

confidence: 99%

Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San

Jia

Long

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…The effect of chronic restraint stress (immobilization for several hours daily in a special restraint chamber for several days) varies possibly due to the influence of hyperlocomotion induced by this type of stressor in the rat [120]: it can decrease immobility (antidepressant-like effect) [95], produce depressive-like behavior in the FST [26,40] or have no significant impact on immobility time [98]. Notably, acute restraint stress produced increased immobility in both weanling [99] and in adult rats [98].…”

Section: Preconditioning and Treatmentsmentioning

confidence: 99%

Factors influencing behavior in the forced swim test

Bogdanova

Kanekar

D’Anci

et al. 2013

Physiology & Behavior

342

216

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The forced swim test (FST) is a behavioral test in rodents which was developed in 1978 by Porsolt and colleagues as a model for predicting the clinical efficacy of antidepressant drugs. A modified version of the FST added the classification of active behaviors into swimming and climbing, in order to facilitate the differentiation between serotonergic and noradrenergic classes of antidepressant drugs. The FST is now widely used in basic research and the pharmaceutical screening of potential antidepressant treatments. It is also one of the most commonly used tests to assess depressive-like behavior in animal models. Despite the simplicity and sensitivity of the FST procedure, important differences even in baseline immobility rates have been reported between different groups, which complicate the comparison of results across studies. In spite of several methodological papers and reviews published on the FST, the need still exists for clarification of factors which can influence the procedure. While most recent reviews have focused on antidepressant effects observed with the FST, this one considers the methodological aspects of the procedure, aiming to summarize issues beyond antidepressant action in the FST. The previously published literature is analyzed for factors which are known to influence animal behavior in the FST. These include biological factors, such as strain, age, body weight, gender and individual differences between animals; influence of preconditioning before the FST: handling, social isolation or enriched environment, food manipulations, various kinds of stress, endocrine manipulations and surgery; schedule and routes of treatment, dosage and type of the drugs as well as experimental design and laboratory environmental effects. Consideration of these factors in planning experiments may result in more consistent FST results.

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“…Another medicinal herb that we tested, BF, is a widely used herbal remedy in Korea, China, and Japan that possesses antidepressant, 28 antioxidative, 29 and antiulcerative 30 properties. In our study, an ethanol extract of BF also exhibited a potent Stat3-inhibitory effect.…”

Section: Discussionmentioning

confidence: 99%

Screening of Stat3 inhibitory effects of Korean herbal medicines in the A549 human lung cancer cell line

Park

Bang

Kim

2014

Integrative Medicine Research

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BackgroundThe transcription factor signal transducer and activator of transcription 3 (Stat3) is constitutively activated in many human cancers. It promotes tumor cell proliferation, inhibits apoptosis, induces angiogenesis and metastasis, and suppresses antitumor host immune responses. Therefore, Stat3 has emerged as a promising molecular target for cancer therapies. In this study, we evaluated the Stat3-suppressive activity of 38 herbal medicines traditionally used in Korea.MethodsMedicinal herb extracts in 70% ethanol were screened for their ability to suppress Stat3 in the A549 human lung cancer cell line. A Stat3-responsive reporter assay system was used to detect intracellular Stat3 activity in extract-treated cells, and Western blot analyses were performed to measure the expression profiles of Stat3-regulated proteins.ResultsFifty percent of the 38 extracts possessed at least mild Stat3-suppressive activities (i.e., activity less than 75% of the vehicle control). Ethanol extracts of Bupleurum falcatum L., Taraxacum officinale Weber, Solanum nigrum L., Ulmus macrocarpa Hance, Euonymus alatus Sieb., Artemisia capillaris Thunb., and Saururus chinensis (Lour.) Baill inhibited up to 75% of the vehicle control Stat3 activity level. A549 cells treated with these extracts also had reduced Bcl-xL, Survivin, c-Myc, and Mcl-1 expression.ConclusionMany medicinal herbs traditionally used in Korea contain Stat3 activity-suppressing substances. Because of the therapeutic impact of Stat3 inhibition, these results could be useful when developing novel cancer therapeutics from medicinal herbs.

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Bupleurum falcatum Prevents Depression and Anxiety-Like Behaviors in Rats Exposed to Repeated Restraint Stress

Cited by 35 publications

References 38 publications

Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San

Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San

Factors influencing behavior in the forced swim test

Screening of Stat3 inhibitory effects of Korean herbal medicines in the A549 human lung cancer cell line

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