“…New AC-BKIs (8,11,14,17) were synthesized and characterized following previously reported procedures (8,12,13) (see Text S1 in the supplemental material). Methods for solubility testing, inhibition of CpCDPK1 and C. parvum cellular growth, drug pharmacokinetic and fecal concentration analysis, plasma protein binding, and determination of efficacy in neonatal mice were performed as previously described (9 Fig.…”