Bullous systemic lupus erythematosus

Elqatni, M.; Qacif, H.; Zyani, M.; Amézyane, T.; Ghafir, D.

doi:10.1016/j.lpm.2017.11.021

Cited by 4 publications

(6 citation statements)

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“…Granular deposition of IgG, IgM, IgA, C3, and C1q has been described on DIF of renal biopsies, unlike in the skin where both granular and linear patterns have been described. 2,8,14,15…”

Section: Systemic Involvementmentioning

confidence: 99%

“…3,11,12 Renal involvement occurs concurrently in approximately 50% of patients, and up to 90% of patients with BSLE develop renal disease in their lifetime. 3,11 Patients present with hematuria and proteinuria, generally attributed to lupus nephritis class III, 11,13 class IV, 11,14 or class V, 15,16 according to the International Society of Nephrology/Renal Pathology Society classification. Granular deposition of IgG, IgM, IgA, C3, and C1q has been described on DIF of renal biopsies, unlike in the skin where both granular and linear patterns have been described.…”

Section: Systemic Involvementmentioning

confidence: 99%

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Bullous systemic lupus erythematosus in females

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Afarideh

Dan

et al. 2022

International Journal of Women’s Dermatology

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Bullous systemic lupus erythematosus (BSLE) is a rare blistering presentation of systemic lupus erythematosus, typically affecting women with the highest incidence in those of African descent. The key pathogenic insult includes the formation of autoantibodies against type VII collagen, which weaken the basement membrane zone and lead to the formation of subepidermal blisters. The acute vesiculobullous eruptions in BSLE generally tend to affect photo-distributed areas, although they can arise unrelated to sun exposure (eg, mucous membranes, axillae). The bullae can arise from erythematous macules, inflammatory plaques, or previously normal skin. Their appearance can range from small, grouped vesicles reminiscent of lesions in dermatitis herpetiformis to large, tense blisters, similar to bullous pemphigoid. Internal organ involvement occurs in up to 90% of those affected. This mostly includes lupus nephritis (classes III-V, lifetime prevalence of up to 90%), arthralgias/arthritis, and cytopenias, while serositis and neuropsychiatric involvement are rare. First-line management with dapsone should be considered in mild disease with stable underlying systemic lupus erythematosus. As discussed in this review, the off-label use of rituximab (an anti-CD20 B-cell depleting agent) has been shown to be safe and effective in several refractory cases of BSLE unresponsive to dapsone, glucocorticoids, or steroid-sparing immunosuppressants.

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“…Granular deposition of IgG, IgM, IgA, C3, and C1q has been described on DIF of renal biopsies, unlike in the skin where both granular and linear patterns have been described. 2,8,14,15…”

Section: Systemic Involvementmentioning

confidence: 99%

Section: Systemic Involvementmentioning

confidence: 99%

Bullous systemic lupus erythematosus in females

Sprow

Afarideh

Dan

et al. 2022

International Journal of Women’s Dermatology

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“…The incidence of this disease with SLE is about 1%. As the knowledge about it is mainly based on case series or reports (7,9). Patients with the vesiculobullous disease usually present with clinical features of SLE, the blisters mainly occur on the oral mucosa, neck, face and upper extremities (10).…”

Section: Discussionmentioning

confidence: 99%

Vesiculobollous disease with Cutaneous Systemic Lupus Erythematosus Treated by Rituxima; a case report

Alla

Ahmed

Essa

et al. 2021

Preprint

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“…As the knowledge about it is mainly based on case series or reports. 7 , 9 Patients with the vesiculobullous disease usually present with clinical features of SLE, the blisters mainly occur on the oral mucosa, neck, face, and upper extremities. 10 All the reported cases indicated these bullae were mostly triggered by sun exposure, they were also tense and heal with no scarring.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of this disease with SLE is about 1%. As the knowledge about it is mainly based on case series or reports 7,9 . Patients with the vesiculobullous disease usually present with clinical features of SLE, the blisters mainly occur on the oral mucosa, neck, face, and upper extremities 10 .…”

Section: Discussionmentioning

confidence: 99%