Bullous pemphigoid with linear lesions and antibodies exclusively against the soluble ectodomain of BP180 (LAD‐1)

Mahmoudi, Hamidreza; Toosi, Roja; Kamyab, Kambiz; Zillikens, Detlef; Schmidt, Enno; Daneshpazhooh, Maryam

doi:10.1111/ddg.13898

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…Interestingly, no circulating anti-BP180 or anti-BP230 antibodies were found, while the patient showed only IgG antibodies directed exclusively against the 120-kDa LAD-1 antigen. 30 …”

Section: Clinical Featuresmentioning

confidence: 99%

Strategies to Improve Outcomes of Bullous Pemphigoid: A Comprehensive Review of Clinical Presentations, Diagnosis, and Patients’ Assessment

Ruggiero¹,

Megna²,

Villani³

et al. 2022

CCID

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Bullous pemphigoid (BP) is the most frequent autoimmune bullous disease mainly affecting elderlies. Diagnosis usually results from clinical features, histological examination, and the quantification of circulating typical autoantibodies, due to its higher incidence in elderly patients, bullous pemphigoid treatment and management still represents a challenge due to the higher frequency of several comorbidities in this group of patients, which may also be linked to a reduced tolerance to BP treatments. Hence, an early diagnosis and a prompt correct treatment are mandatory to reach better clinical outcomes and improve as much as possible BP outcomes. Herein, we carried out a comprehensive literature review about the known clinical presentations, diagnosis, assessment and monitoring procedures used in daily clinical practice in patients with BP, to better define strategies to improve as much as possible BP clinical outcomes.

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“…Interestingly, no circulating anti-BP180 or anti-BP230 antibodies were found, while the patient showed only IgG antibodies directed exclusively against the 120-kDa LAD-1 antigen. 30 …”

Section: Clinical Featuresmentioning

confidence: 99%

Strategies to Improve Outcomes of Bullous Pemphigoid: A Comprehensive Review of Clinical Presentations, Diagnosis, and Patients’ Assessment

Ruggiero¹,

Megna²,

Villani³

et al. 2022

CCID

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“…The most frequent nail abnormalities among the patients were ridging, onycholysis, onychoschizia, periungual bullae, nail thickening, nail dystrophy, and yellow discoloration. Nail involvement because of the course of disease in patients with SEABD is not common 10,12,17,25,26 . There is an area of relative immune privilege in the nail apparatus similar to that of the hair follicle which serves as a protection against destructive immune responses 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Nail involvement because of the course of disease in patients with SEABD is not common. 10,12,17,25,26 There is an area of relative immune privilege in the nail apparatus similar to that of the hair follicle which serves as a protection against destructive immune responses. 11 In BP, paronychia, onychorrhexis, Beau's lines, onychomadesis, subungual hyperkeratosis, longitudinal melanonychia, pterygium, dystrophy, onycholysis, and nail loss have been previously reported.…”

Section: Discussionmentioning

confidence: 99%

Nail abnormalities in subepidermal blistering diseases: a cross‐sectional study

et al. 2023

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Background Nail involvement in subepidermal autoimmune blistering diseases (SEABD) is not common. Although these changes can be transient, permanent changes can also occur. This study addresses nail involvement manifestations and their associated factors in patients with SEABD.Methods From March 2020 to March 2021, we enrolled 56 patients with SEABD who were being examined at a tertiary skin hospital and checked their nail changes. We investigated the association between the SEABD subtypes and treatments that patients were receiving and the nail abnormalities. Additional factors including age, gender, duration since diagnosis, presence of mucosal involvement, and anti-bp230 and anti-bp180 IgG antibody quantitative levels (in those patients with bullous pemphigoid) were analyzed. ResultsThe most common nail abnormalities were ridging, onycholysis, and onychoschizia. We observed a lower prevalence of onycholysis in EBA, a lower prevalence of periungual bullae in MMP, and a higher prevalence of scarring loss in EBA. Rituximab and dapsone were effective in preventing onycholysis as well as prednisolone in preventing subungual hematoma. Multiple lesions were found to be more common in the foot digits including great toes, probably because of higher exposure to trauma.Conclusions In summary, in patients with SEABD and concomitant nail involvement, the underlying disease control, proper treatment, and avoidance of trauma may be helpful.

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“…ized by antibodies against BP180 and BP230. 1 Palmoplantar keratoderma (PPK) is defined as hyperkeratosis of palms and soles. 2 Here we report three BP cases developing acquired PPK (Table 1) along with review literature.…”

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confidence: 99%

Concomitant bullous pemphigoid and palmoplantar keratoderma: A report of three cases and review of literature

Sadeghi

Nili

Tavakolpour

et al. 2020

Dermatologic Therapy

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Bullous pemphigoid with linear lesions and antibodies exclusively against the soluble ectodomain of BP180 (LAD‐1)

Cited by 3 publications

References 9 publications

Strategies to Improve Outcomes of Bullous Pemphigoid: A Comprehensive Review of Clinical Presentations, Diagnosis, and Patients’ Assessment

Strategies to Improve Outcomes of Bullous Pemphigoid: A Comprehensive Review of Clinical Presentations, Diagnosis, and Patients’ Assessment

Nail abnormalities in subepidermal blistering diseases: a cross‐sectional study

Concomitant bullous pemphigoid and palmoplantar keratoderma: A report of three cases and review of literature

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