Bullous pemphigoid in children

Robinson, J. W.

doi:10.1001/archderm.114.6.899

Cited by 23 publications

(5 citation statements)

References 31 publications

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“…Elevated total serum IgE levels have been described in multiple reports in 70-85% of BP sera and blister fluids [41][42][43][44][45][46][47][48][49][50] and have also been found in children with BP [11] and linear IgA disease. [51] Interestingly, in a case report, a mother with pemphigoid gestationis, but not the newborn, had elevated total IgE levels.…”

Section: Elevated Total Serum Ige Levelsmentioning

confidence: 99%

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IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases

Beek

Schulze

Zillikens

et al. 2015

Expert Review of Clinical Immunology

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Autoimmune bullous diseases (AIBDs) are characterized by autoantibodies against structural proteins of the dermal-epidermal junction (in pemphigoid diseases) and the epidermal/ epithelial desmosomes (in pemphigus diseases). By far, the most common AIBD is bullous pemphigoid, which is immunopathologically characterized by autoantibodies against BP180 (type XVII collagen) and BP230. IgG and, to a lesser extent, IgA autoantibodies are the major autoantibody isotypes in these disorders. IgE autoantibodies are increasingly reported in particular in bullous pemphigoid. The development of specific and sensitive anti-BP180 IgE ELISA systems, the report of two experimental murine models employing IgE autoantibodies against BP180, and the successful treatment of bullous pemphigoid with the anti-IgE antibody omalizumab have raised interest in the role of IgE autoantibodies and the modulation of their production in AIBDs. Here, the relevance of IgE autoantibodies in the diagnosis, pathophysiology, and treatment decisions of AIBDs, with a focus on bullous pemphigoid, is reviewed. ARTICLE HISTORY

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Section: Elevated Total Serum Ige Levelsmentioning

confidence: 99%

“…[9] Only a few cases have been reported in infants and adolescents. [10,11] BP patients present with tense blisters and erythema predominantly in flexures of limbs and abdomen, often in conjunction with urticarial plaques. By mechanical friction, blisters may turn into erosions and finally crusts before healing.…”

Section: Introductionmentioning

confidence: 99%

IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases

Beek

Schulze

Zillikens

et al. 2015

Expert Review of Clinical Immunology

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“…The risk of appearance of BP in people over the age of 90 years seems to be almost 300‐fold higher than in people under the age of 60 7 . However, its appearance has also been rarely reported in young adults and children 8 …”

Section: Introductionmentioning

confidence: 97%

“…7 However, its appearance has also been rarely reported in young adults and children. 8 BP is considered to be a chronic relapsing disease. 9 It has been mentioned to be significantly correlated with a high morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Mortality and prognostic factors of Bullous Pemphigoid in a Moroccan population

Titou

Hjira

2022

Aust J Dermatology

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Background: Bullous pemphigoid is a common autoimmune blistering skin disease that is significantly associated with a high rate of morbidity and mortality.Objective: Our aim was to determine the 1-, 2-and 3-year mortality rate and standardized mortality ratio of BP in Moroccan patients, as well as to identify risk factors that influence survival both in the 1st and 3rd year of follow-up.Methods: All patients with BP diagnosed between January 2008 and December 2017 in a tertiary referral centre at the Mohammed V Military Hospital in Morocco were included retrospectively. Results:The 1-year, 2-year and 3-year mortality rates of the cases were 25.8%, 32.3% and 43%, respectively. The median age of onset was 72 years (range, 64 ∼ 80 years), and 51 (54.8%) patients were men. The standardized mortality ratio of patients with BP was 2.6 times higher than that of age-and sex-matched members of the general Moroccan population. Besides advanced age, the presence of diabetes mellitus at the time of diagnosis was associated with increased 3-year mortality in multivariate analysis. Conclusion:This is the first study analysing the mortality rate of bullous pemphigoid in Morocco. Our findings confirm a high mortality rate for BP patients compared with the expected mortality rate for age-and sex-adjusted general Moroccan population. Risk factors for increased 3-year mortality include advanced age at the time of diagnosis and diabetes mellitus.

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“…[1][2][3][4] Em 1967, Jordon et al evidenciaram pela primeira vez a presença de anticorpos subepidérmicos no penfigóide bolhoso, 2 e, em 1970, Bean et al 5 descreveram o primeiro caso de PB em criança, confirmado pela imunofluorescência. 2,3,5 Desde então, cerca de 50 casos foram descritos, sendo apenas 10 em crianças com menos de um ano de idade. 1,6 O diagnóstico diferencial com outras buloses da infância, como a dermatite herpetiforme ou dermatose bolhosa por IgA linear, pode ser difícil, pois muitas vezes elas apresentam semelhanças clínicas e histopatológicas.…”

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Penfigóide bolhoso no lactente

Quattrino

Silveira

Kawakubo

et al. 2007

An. Bras. Dermatol.

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O penfigóide bolhoso é doença que comumente acomete pessoas idosas. Desde o primeiro caso na infância, confirmado por imunofluorescência em 1970, cerca de 50 casos foram relatados e poucos ocorreram em crianças com menos de um ano de idade. Apresentase caso de penfigóide bolhoso em lactente de quatro meses de idade e discutem-se as características clínicas e imunopatológicas dessa rara bulose da infância.

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Bullous pemphigoid in children

Cited by 23 publications

References 31 publications

IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases

IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases

Mortality and prognostic factors of Bullous Pemphigoid in a Moroccan population

Penfigóide bolhoso no lactente

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