Bullous Pemphigoid in an 11-Year-Old Boy

Bean, Samuel F.; Good, Robert A.; Windhorst, Dorothy B.

doi:10.1001/archderm.1970.04000080077015

Cited by 103 publications

(45 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One theory suggests that the offending medication possibly behaves as an antigenic hapten inducing antibodies to the basement membrane zone via binding to a protein in the lamina lucida and somehow uncovering a hidden antigenic site and altering its antigenic properties [15][16][17]. Alternatively, another mechanism proposed that medication-induced antibody production alters T suppressor cell function which then no longer represses certain B cell clones [15].…”

Section: Discussionmentioning

confidence: 99%

Erythema Multiforme-Like Bullous Pemphigoid Associated with Furosemide

Hirano¹,

Mason²,

Harvey³

et al. 2011

J Clin Exp Dermatol

View full text Add to dashboard Cite

An 80-year-old woman with celiac sprue presented with an acute bullous eruption on the bilateral flexural forearms. She had coincident onset of diarrhea and vomiting which led to dehydration, renal failure, and hospitalization. She denied a history of similar eruptions. Prehospitalization medications were unchanged over the past year and included clonidine, olmesartan, simvastatin, diphenoxylate/atropine, omeprazole, and furosemide.Cutaneous examination revealed erythematous targetoid plaques with dusky centers symmetrically distributed on the chin, neck, flexural forearms, central chest, breasts, flanks, inner thighs, and anterior legs ( Figure 1 and Figure 2). In addition, there were numerous tense vesicles and bullae in the same distribution (Figure 1). Palms, soles, and mucous membranes were spared. Laboratory studies revealed a mild leukocytosis and findings consistent with acute renal failure. AbstractThe clinical diagnosis of bullous pemphigoid (BP) can be challenging given the polymorphic nature of the disease. We present a case of erythema multiforme (EM)-like BP in an 80-year-old woman with celiac disease. Skin biopsies showed intraepidermal and subepidermal bullae with direct immunofluorescence (DIF) demonstrating IgG and C3 linear deposition at the basement membrane. The etiology of our patient's BP is unclear but may be associated with furosemide usage and is temporally associated with a flare of celiac sprue. To our knowledge, only four other published cases document EM-like lesions in BP. Atypical presentations of BP should be confirmed with histology and direct immunofluorescence.

show abstract

Section: Discussionmentioning

confidence: 99%

Erythema Multiforme-Like Bullous Pemphigoid Associated with Furosemide

Hirano¹,

Mason²,

Harvey³

et al. 2011

J Clin Exp Dermatol

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4] Em 1967, Jordon et al evidenciaram pela primeira vez a presença de anticorpos subepidérmicos no penfigóide bolhoso, 2 e, em 1970, Bean et al 5 descreveram o primeiro caso de PB em criança, confirmado pela imunofluorescência. 2,3,5 Desde então, cerca de 50 casos foram descritos, sendo apenas 10 em crianças com menos de um ano de idade. 1,6 O diagnóstico diferencial com outras buloses da infância, como a dermatite herpetiforme ou dermatose bolhosa por IgA linear, pode ser difícil, pois muitas vezes elas apresentam semelhanças clínicas e histopatológicas.…”

unclassified

“…2,5 O uso das sulfonas isoladamente é controverso, encontrando-se relatos de sucesso e de fracasso com a droga, 2 mas o uso da dapsona ou sulfapiridina como terapia adjunta à corticoterapia pode ser benéfico. 2 A combinação de eritromicina e nicotinamida também é mencionada por alguns autores como alternativa segura aos esteróides orais.…”

unclassified

Penfigóide bolhoso no lactente

Quattrino

Silveira

Kawakubo

et al. 2007

An. Bras. Dermatol.

View full text Add to dashboard Cite

O penfigóide bolhoso é doença que comumente acomete pessoas idosas. Desde o primeiro caso na infância, confirmado por imunofluorescência em 1970, cerca de 50 casos foram relatados e poucos ocorreram em crianças com menos de um ano de idade. Apresentase caso de penfigóide bolhoso em lactente de quatro meses de idade e discutem-se as características clínicas e imunopatológicas dessa rara bulose da infância.

show abstract

“…In the last years many cases of BP associated with UC have been reported [4][5][6][7][8] but it is difficult to establish a pathogenetic link between the two diseases. In a large case-control study, Taylor et al [1] did not find an increased incidence of auto-immune disorders in subjects with BP compared to a control population; Harrison et al [8] instead suggest that HLA-D8 may predispose to BP associated with UC with colonic antigens possibly cross-reacting with cutaneous antigens.…”

mentioning

confidence: 99%

“…Since Bean et al [4] described an 11-year-old boy presenting a BP after receiving salicylazosulphapyridine, several cases of BP or BPlike eruption have been reported following the use of many drugs [2,3].…”

mentioning

confidence: 99%