Bullous pemphigoid associated with silicosis

Zhu, Tao; Ma, D L; Song, Lei; Li, L

doi:10.1111/jdv.14419

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…In most cases, the disease develops cryptically ( 2 ). The suggested causes of BP include silicosis ( 3 ), psoralen and ultraviolet A therapy ( 4 ), infections ( 5 ), physical or chemical insults ( 6 – 8 ), certain fruits ( 9 ), and medications ( 10 , 11 ). However, the validation of these factors in the pathogenesis of BP remains be established.…”

Section: Introductionmentioning

confidence: 99%

BP180 Is Critical in the Autoimmunity of Bullous Pemphigoid

Liu

Xia

2017

Front. Immunol.

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Bullous pemphigoid (BP) is by far the most common autoimmune blistering dermatosis that mainly occurs in the elderly. The BP180 is a transmembrane glycoprotein, which is highly immunodominant in BP. The structure and location of BP180 indicate that it is a significant autoantigen and plays a key role in blister formation. Autoantibodies from BP patients react with BP180, which leads to its degradation and this has been regarded as the central event in BP pathogenesis. The consequent blister formation involves the activation of complement-dependent or -independent signals, as well as inflammatory pathways induced by BP180/anti-BP180 autoantibody interaction. As a multi-epitope molecule, BP180 can cause dermal–epidermal separation via combining each epitope with specific immunoglobulin, which also facilitates blister formation. In addition, some inflammatory factors can directly deplete BP180, thereby leading to fragility of the dermal–epidermal junction and blister formation. This review summarizes recent investigations on the role of BP180 in BP pathogenesis to determine the potential targets for the treatment of patients with BP.

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