Bullous Pemphigoid and Other Pemphigoid Dermatoses

Pratasava, Valeryia; Sahni, Vikram N; Suresh, Aishwarya; Huang, Simo; Are, Abhirup; Hsu, Sylvia; Motaparthi, Kiran

doi:10.3390/medicina57101061

Cited by 16 publications

(17 citation statements)

References 49 publications

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“…Pemphigoid corresponds to a group of dermatological diseases, characterized by the formation of autoantibodies against hemidesmosomes ( 25 - 27 ). This group may be divided into bullous and mucous membrane pemphigoid ( 26 ) however, besides these lesions sharing some characteristics, they present significant differences in clinical course, treatment, and prognosis ( 1 , 25 - 28 ). In general, they preferentially affect women between the sixth and seventh decades of life ( 25 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…This group may be divided into bullous and mucous membrane pemphigoid ( 26 ) however, besides these lesions sharing some characteristics, they present significant differences in clinical course, treatment, and prognosis ( 1 , 25 - 28 ). In general, they preferentially affect women between the sixth and seventh decades of life ( 25 , 27 ). In the mucous membrane pemphigoid, the gingiva is affected in 94% of cases, causing desquamative gingivitis ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

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Mucocutaneous diseases with manifestations in the head and neck region: 24 years of experience in a Dermatology service

Silva

Lima-Souza²,

Silva³

et al. 2023

Med Oral

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Background This study aimed to evaluate the clinicopathological features of mucocutaneous diseases with manifestation in the head and neck region. Material and Methods A retrospective analysis of a dermatology reference center database was carried out. Over 24 years. Clinicopathological data were collected from medical records and the data was analyzed by descriptive statistics. Results A total of 11.538 medical records were analyzed, being 152 cases of mucocutaneous diseases with manifestations in the head and neck region. Cutaneous lupus erythematosus was the most prevalent diagnosis (66.4%). Face (44.1%), females (79.6%), and patients with 45 years mean age were the most common features. In the oral cavity, the most affected region was the buccal mucosa (37.5%). Conclusions Mucocutaneous diseases with head and neck manifestation were rare in the sample analyzed (1.3%), with cutaneous lupus erythematosus and lichen planus being the most common lesions in this region. Key words: Mucocutaneous diseases, head and neck, oral lesion, lichen planus, lupus erythematosus, pemphigus, pemphigoid.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mucocutaneous diseases with manifestations in the head and neck region: 24 years of experience in a Dermatology service

Silva

Lima-Souza²,

Silva³

et al. 2023

Med Oral

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“…The disease activity can be rated based on a general overall perception using this scoring method. The primary clinician also classifies patients as having mild, moderate, or severe illness (52).…”

Section: Differential Diagnosismentioning

confidence: 99%

Recurrent bullous pemphigoid: A case report and literature review

et al. 2023

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The present study aimed to enhance the current understanding of the etiopathogenesis, predisposing factors, clinical features and current management modalities for bullous pemphigoid (BP). BP is a chronic autoimmune disorder mediated by antibodies targeting BP180, a type XVII collagen (BPAG2), and BP230, a hemidesmosome protein located in basal keratinocytes, resulting in the formation of subepithelial blisters and multiple chronic oral ulcers, which heal without scarring, as well as urticarial lesions on the extremities. The BP lesions occur in the oral cavity following the onset of pruritic papules in the extremities. The present study describes the case of a patient with recurrent BP who was hypertensive and treated with amlodipine. In addition, a detailed search was performed on the PubMed database by searching the key word 'bullous pemphigoid'; ~33 articles were selected which were published from 2005-2022 for inclusion and discussion in the literature review. Studies published prior to 2005 were excluded. The anti-hypertensive drug, amlodipine, has a high propensity for BP lesions. However, caution needs to be taken when prescribing amlodipine for hypertension. The occurrence of BP must not be overlooked, and the oral physician must seek a complete detailed drug history and clinical examination, which will aid in the diagnosis of BP. BP lesions are usually multiple and have a chronicity and usually affects the oral mucosa, upper torso and arms. There is a period of exacerbations and remissions. On the whole, the present study provides insight into the etiology, predisposing risk factors, etiopathogenesis, clinical features and management modalities for BP.

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“…The oral mucosa may be involved in approximately 50% of the cases, with erosions or intact oral vesicles. They can be hemorrhagic and can result in erosions, crusts and scars [ 75 , 76 ]. MMP-like EBA is characterized by predominant involvement of the mucosa, with lesions and scarring most often in the oral cavity; eye involvement leading to blindness has also been reported [ 53 ].…”

Section: Oral Manifestations In Selected Diseasesmentioning

confidence: 99%

Immunoglobulin Disorders and the Oral Cavity: A Narrative Review

Ptasiewicz

Bębnowska

Małkowska

et al. 2022

JCM

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The oral mucosa is a mechanical barrier against the penetration and colonization of microorganisms. Oral homeostasis is maintained by congenital and adaptive systems in conjunction with normal oral flora and an intact oral mucosa. Components contributing to the defense of the oral cavity include the salivary glands, innate antimicrobial proteins of saliva, plasma proteins, circulating white blood cells, keratinocyte products of the oral mucosa, and gingival crevicular fluid. General disturbances in the level of immunoglobulins in the human body may be manifested as pathological lesions in the oral mucosa. Symptoms of immunoglobulin-related general diseases such as mucous membrane pemphigoid (MMP), pemphigus vulgaris (PV), linear IgA bullous dermatosis (LABD), Epidermolysis Bullosa Aquisita (EBA), and Hyper-IgE syndrome (HIES) may appear in the oral cavity. In this review, authors present selected diseases associated with immunoglobulins in which the lesions appear in the oral cavity. Early detection and treatment of autoimmune diseases, sometimes showing a severe evolution (e.g., PV), allow the control of their dissemination and involvement of skin or other body organs. Immunoglobulin disorders with oral manifestations are not common, but knowledge, differentiation and diagnosis are essential for proper treatment.

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Bullous Pemphigoid and Other Pemphigoid Dermatoses

Cited by 16 publications

References 49 publications

Mucocutaneous diseases with manifestations in the head and neck region: 24 years of experience in a Dermatology service

Mucocutaneous diseases with manifestations in the head and neck region: 24 years of experience in a Dermatology service

Recurrent bullous pemphigoid: A case report and literature review

Immunoglobulin Disorders and the Oral Cavity: A Narrative Review

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