Bullous pemphigoid after second dose of mRNA- (Pfizer-BioNTech) Covid-19 vaccine: A case report

Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

“…136 Moreover, 40 cases of pemphigoids have been described. [137][138][139][140][141][142][143][144][145][146][147][148][149][150][151] Regarding other cutaneous diseases developed following COVID-19 vaccination, 9, 40, 55, 12 and 11 cases of morphea, [152][153][154][155][156][157] pityriasis rosea, [158][159][160][161][162][163][164][165][166][167][168][169][170][171][172][173][174][175][176][177] herpes zoster, [178][179][180][181][182][183][184]…”

“… BNT162b2: 14 mRNA-1273: 4 AZD1222: 6 Ad26.COV2: 0 Pemphigus vulgaris 26 Martora et al 121 (7), Zou et al 122 (3), Gui et al 123 (2), Rouatbi et al 124 (2), Aryanian et al 125 (1), Koutlas et al 126 (1), Knechtl et al 127 (1), Ong et al 128 (1), Yıldırıcı et al 129 (1), Singh et al 130 (1), Norimatsu et al 131 (1), Agharbi et al 132 (1), Almasi-Nasrabadi et al 133 (1), Corrá et al 134 (1), Solimani et al 135 (1). BNT162b2: 15 mRNA-1273: 6 AZD1222: 5 Ad26.COV2: 0 Pemphigoids 40 Maronese et al 137 (21), Maronese et al 138 (3), Hali et al 139 (3), Gambichler et al 140 (2), Shanshal et al 141 (1), Desai et al 142 (1), Fu et al 143 (1), Alshammari et al 144 (1), Hung et al 145 (1), Pauluzzi et al 146 (1), Dell’Antonia et al 147 (1), Pérez-López et al 148 (1), Agharbi et al 149 (1), Young et al 150 (1), Nakamura et al 151 (1). BNT162b2: 29 mRNA-1273: 5 AZD1222: 6 Ad26.COV2: 0 Morphea 9 Paolino et al 152 (4), Antoñanzas et al 153 (2), Oh et al 154 (1), Metin et al 155 (1), Aryanian et al 156 (1).…”

Local bullous reaction as a cutaneous reaction after mRNA‐boosted vaccination in a post‐COVID patient

“… 2 , 3 , 4 , 5 Some bullous reactions from the mRNA vaccine were also reported. 6 , 7 , 8 , 9 However, limited data exist about cutaneous reactions from the booster vaccine in combination regimens, especially in post‐COVID 19 infectious patients.…”

“…Many adverse cutaneous reactions were reported after receiving an mRNA vaccine, typically presenting as delayed large local reactions, swelling, erythema, urticarial and morbilliform rashes, and exacerbation or flares of existing dermatologic conditions 2–5 . Some bullous reactions from the mRNA vaccine were also reported 6–9 . However, limited data exist about cutaneous reactions from the booster vaccine in combination regimens, especially in post‐COVID 19 infectious patients.…”

A Systematic Review of Histopathologic Surveys on Mucocutaneous Biopsies in Patients Developed COVID-19 Vaccine-Related Dermatologic Manifestations

“…Panepidermal necrosis along with a significant sparse lymphocytic infiltrate, 47,57,113,114 suprabasal epithelial splitting, and C3 depositions were noted in the histopathologic evaluation. [115][116][117][118][119][120][121] Furthermore, papulosquamous exanthema (cutaneous lupus erythematous) was observed after vaccination; vacuolar interface or spongiotic dermatitis, significant lymphocytic and eosinophilic infiltrates, and slight deposition of mucin into dermis were detected in microscopy. [122][123][124][125][126] A histopathologic study of a delayed large local reaction in a middle-aged woman revealed extensive lymphohistiocytic infiltrates with CD3 + (including CD8 + and CD4 + ) T cells and some eosinophils.…”