Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: Three cases

Modificação química da pectina do melão caipira (Cucumis melo var. Acidulus)

“…Porém, diversos efeitos adversos da heparina têm sido descritos, como por exemplo: hemorragia, trombocitopenia, necrose quando aplicada por via subcutânea e osteoporose. 6 Somados aos efeitos adversos, a heparina apresenta uma diversidade estrutural, problemas com contaminação por patógenos animais e poucas fontes de extração, 7 o que justifica a busca de novos compostos com atividades semelhantes, com menos efeitos adversos e que sejam provenientes de fontes não animais.…”

Intracranial hemorrhage with fatal outcome in a patient with heparin induced bullous hemorrhagic dermatosis

“…Although the platelet count of 110.000 is not low, it is enough to be directly related to intracranial hemorrhage; more than 50% decrease within platelet count is important for a causal relationship. In addition to our observation, we intended to state the clinical characteristics of previously reported cases related to mortality and we could attain 4 cases up to date 2,4 . Causes of death in these cases were stated to be sepsis for one patient, intracranial hemorrhage for two patients and were not defined in one case.…”

Hemorrhagic Bullous Dermatosis

“…Direct immunofluorescence and heparin platelet factor 4 have all been negative in prior case reports. [4][5][6][7] Only one of the ten cases has reported unfractionated heparin as an inciting agent for hemorrhagic bullosis, 8 while the remaining have been from LMWH. The age range of affected patients in case reports were 50-90 years old with several having a history of malignancy.…”