Bullous eczema presenting as bullous pemphigoid-like eruption: A case series

Atteh, George; Cole, Emily F.; Perricone, Adam; Feldman, Ron J.

doi:10.1016/j.jdcr.2021.01.032

Cited by 2 publications

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References 8 publications

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“…In this regard, one study reported a group of patients with clinical signs suggestive of BP, but with no characteristic histopathological and serological features. Biopsies showed in these cases only eosinophilic spongiosis, demonstrating either a particular form of bullous eczema or a BP with a prolonged incipient stage ( 25 ). BP shows subepidermal bullae with lymphocytes, eosinophils, neutrophils, plasma, and fibrin, in mature lesions ( 11 ).…”

Section: Spongiosis Patterns In Autoimmune Bullous Dermatosesmentioning

confidence: 95%

Spongiotic reaction patterns in autoimmune bullous dermatoses (Review)

et al. 2021

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Spongiosis or a spongiotic reaction pattern is the histological hallmark of intercellular epidermal edema, viewed as clear spaces within the epidermis. Although considered a histopathological term, spongiosis has clinical correlations, with the variable degrees of spongiotic reaction leading to different dermatological findings. This review aimed to highlight the spongiotic reactive patterns found in different autoimmune bullous dermatoses, considering the paucity of publications in this domain. The pathogenesis of spongiosis assumes the passage of extravasated edema fluid from the dermis into the epidermis, frequently accompanied by dermal inflammatory cells, and classification of the spongiotic reaction patterns, as well as their associated spongiotic dermatitis, take into consideration the type and distribution of these inflammatory cells. It is mandatory to consider different reactive processes, specific for other skin disorders, which act as simulants of different spongiotic patterns for the diagnosis. Considering the possible transient occurrence, the heterogeneity and non-specificity of the histopathological features of these diseases, the diagnosis is very complex, requiring clinicopathological correlations and additional analyses. A deep insight into spongiosis pathogeny may open the perspectives of a classification refinement of autoimmune bullous dermatoses.

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Section: Spongiosis Patterns In Autoimmune Bullous Dermatosesmentioning

confidence: 95%