A case of bullous arthropod bite reaction occurs following the bite of an arthropod, resulting in edema and eruption of blisters on the affected area, as it is a challenging task to differentiate it from cellulitis, especially in the early course of the reaction. So, early diagnosis is required to prevent the unnecessary use of antibiotics and no delay in managing arthropod bite reaction. The natural history of the disease begins with marked edema with erythema at the bite and surrounding sites. It is followed by single/multiple bulla formation depending upon the number of bites. Then it ruptures, and a serous fluid is released, which is then followed by the formation of granulation tissue a week or two later. Appropriate wound care with soap and water is required to prevent superimposed bacterial infection. Differential diagnoses of cellulitis and necrotizing fasciitis can be excluded by lack of systemic signs and symptoms like fever, malaise, or weakness. Treatment generally involves symptomatic relief of pain and pruritus, including nonsteroidal anti-inflammatory drugs (NSAIDs) and antihistaminic.