Bullfrogs (Lithobates catesbeianus) as a Potential Source of Foodborne Disease

Zepeda-Velázquez, Andrea Paloma; Gómez-De-Anda, Fabián-Ricardo; Aguilar-Mendoza, Luis F.; Castrejón-Jiménez, Nayeli S.; Hernández-González, Juan C.; Varela-Guerrero, Jorge A.; de-la-Rosa-Arana, Jorge-Luis; Vega-Sánchez, Vicente; Rodríguez, Nydia Edith Reyes

doi:10.1016/j.jfp.2023.100067

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Cited by 4 publications

References 68 publications

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Ferric uptake regulator (fur) affects the pathogenicity of Aeromonas veronii TH0426 by regulating flagellar assembly and biofilm formation

Gong,

Wang,

Jiang

et al. 2024

Aquaculture

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Ferric uptake regulator (fur) affects the pathogenicity of Aeromonas veronii TH0426 by regulating flagellar assembly and biofilm formation

Gong,

Wang,

Jiang

et al. 2024

Aquaculture

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Intestinal flora analysis and serum metabolomics reveal the effectiveness of Bacillus coagulans BC66 in treating bacterial enteritis in bullfrogs

Su,

Gao,

Shu

et al. 2025

Aquaculture

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Outbreaks of Elizabethkingia miricola Caused Fatal Meningitis-Like Disease in Cultured Bullfrogs

An,

Hou,

Sun

et al. 2024

Transboundary and Emerging Diseases

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Elizabethkingia miricola is an emerging nosocomial pathogen responsible for meningitis, sepsis, urinary tract infection, pneumonia, and joint infection in humans. These pathogens were also reported to be causal agents for meningitis-like disease in cultured frogs, which displayed high infectivity, mortality, and significant loss. In July 2023, 10 outbreaks of infectious meningitis-like disease in bullfrogs occurred in Tangshan area. To determine the causal agent, 70 diseased frogs from 10 farms were collected for etiological identification. Gram-negative bacilli were isolated from the brain and liver of sick bullfrogs and identified as members of E. miricola by biochemical characterization and 16S rRNA sequencing analysis. A total of 42 strains of E. miricola were isolated and further determined as the etiological agent by reproducing neurological symptoms and deaths in an artificial infection test. A representative isolate, HBTS-1, was picked up for the pathogenicity test, and the data showed that this stain was highly pathogenic to bullfrogs with an LD50 of 3.7 × 105 CFU. Notably, the isolate also showed high pathogenicity to 5-day-old suckling mice, with an LD50 of 3.1 × 106 CFU, indicating its potential threat to mammals. Moreover, all the 42 E. miricola isolates showed resistance to multiple antibotics without an apparent inhibition zone observed in the test, making the choice of antimicrobial therapy challenging. These novel findings prioritized E. miricola as an important zoonotic agent, which may provide a reference for human medicine.

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Bullfrogs (Lithobates catesbeianus) as a Potential Source of Foodborne Disease

Cited by 4 publications

References 68 publications

Ferric uptake regulator (fur) affects the pathogenicity of Aeromonas veronii TH0426 by regulating flagellar assembly and biofilm formation

Ferric uptake regulator (fur) affects the pathogenicity of Aeromonas veronii TH0426 by regulating flagellar assembly and biofilm formation

Intestinal flora analysis and serum metabolomics reveal the effectiveness of Bacillus coagulans BC66 in treating bacterial enteritis in bullfrogs

Outbreaks of Elizabethkingia miricola Caused Fatal Meningitis-Like Disease in Cultured Bullfrogs

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