Bullae-Forming Pulmonary Metastasis from Choriocarcinoma Presenting as Pneumothorax

Hyun, Kyung; Jeon, Hyeon Woo; Kim, Kyung Soo; Choi, Kook Bin; Park, Jae Kil; Park, Hyung Joo

doi:10.5090/kjtcs.2015.48.6.435

Cited by 7 publications

(7 citation statements)

References 6 publications

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“…Other patterns of pulmonary metastatic disease have been reported and can be detected with chest CT. A common pattern is a small nodule sur-rounded by a halo of ground-glass attenuation, the so-called halo sign, which results from peritumoral hemorrhage (Fig 17) (59). Cavitary and bulla-forming pulmonary metastases may occur, which can result in pneumothorax (60,61).…”

Section: Imaging Of Distant Metastasesmentioning

confidence: 99%

Gestational Trophoblastic Disease: Clinical and Imaging Features

et al. 2017

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Gestational trophoblastic disease (GTD) is a spectrum of both benign and malignant gestational tumors, including hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The latter four entities are referred to as gestational trophoblastic neoplasia (GTN). These conditions are aggressive with a propensity to widely metastasize. GTN can result in significant morbidity and mortality if left untreated. Early diagnosis of GTD is essential for prompt and successful management while preserving fertility. Initial diagnosis of GTD is based on a multifactorial approach consisting of clinical features, serial quantitative human chorionic gonadotropin (β-hCG) titers, and imaging findings. Ultrasonography (US) is the modality of choice for initial diagnosis of complete hydatidiform mole and can provide an invaluable means of local surveillance after treatment. The performance of US in diagnosing all molar pregnancies is surprisingly poor, predominantly due to the difficulty in differentiating partial hydatidiform mole from nonmolar abortion and retained products of conception. While GTN after a molar pregnancy is usually diagnosed with serial β-hCG titers, imaging plays an important role in evaluation of local extent of disease and systemic surveillance. Imaging also plays a crucial role in detection and management of complications, such as uterine and pulmonary arteriovenous fistulas. Familiarity with the pathogenesis, classification, imaging features, and treatment of these tumors can aid in radiologic diagnosis and guide appropriate management. RSNA, 2017.

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Section: Imaging Of Distant Metastasesmentioning

confidence: 99%

Gestational Trophoblastic Disease: Clinical and Imaging Features

et al. 2017

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“…In the literature, a handful of reports of these rare pulmonary complications have been described. A case of bullae-forming choriocarcinoma with PTX formation was reported in South Korea ( Hyun et al, 2015 ). A case of intermediate trophoblastic disease presenting as PTX was reported in 2015 ( Multani et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Acute pulmonary complications in the setting of high risk gestational trophoblastic neoplasia and induction of chemotherapy

Khadraoui

Herzog

Jackson

et al. 2023

Gynecologic Oncology Reports

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“…On CT a common pattern is a peripheral ground-glass attenuation surrounding the nodules (halo sign), which results from peritumoral hemorrhage [14] . In some cases, cavitary and bulla-forming pulmonary metastases may occur, which can result in pneumothorax [15] . Brain metastases are usually multiple, located at grey-white matter junctions, with hemorrhage and surrounding edema.…”

Section: Discussionmentioning

confidence: 99%

Metastatic choriocarcinoma with hemorrhagic complications and spontaneous ovarian hyperstimulation syndrome: A case report

Lucia

Castaldo

D'Agostino

et al. 2021

Radiology Case Reports

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Gestational choriocarcinoma is a malignant trophoblastic tumor arising from any gestational event, even with a long latency period, generally in the reproductive female. It is associated with a high level of beta-human chorionic gonadotropin. Its primary site is usually the uterus but not all patients have a detectable lesion in this site. Regression of the primary tumor after it has metastasized is not uncommon, and one-third of cases manifest as complications of metastatic disease. In this report we present an uncommon case of gestational choriocarcinoma with lung, liver and jejunal metastases at the time of diagnosis without evidence of pelvic disease, in 34-year-old woman. The main points of interest of our case were the development of the ovarian hyperstimulation syndrome with massive multicystic ovarian enlargement induced by high level of beta-human chorionic gonadotropin and the bleeding of jejunal and liver metastases, due to the high vascularity of the tumor tissue, a condition known as “Choriocarcinoma Syndrome”. We will focus on the radiological findings of metastases, bleeding complications and ovarian hyperstimulation syndrome.

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Bullae-Forming Pulmonary Metastasis from Choriocarcinoma Presenting as Pneumothorax

Cited by 7 publications

References 6 publications

Gestational Trophoblastic Disease: Clinical and Imaging Features

Gestational Trophoblastic Disease: Clinical and Imaging Features

Acute pulmonary complications in the setting of high risk gestational trophoblastic neoplasia and induction of chemotherapy

Metastatic choriocarcinoma with hemorrhagic complications and spontaneous ovarian hyperstimulation syndrome: A case report

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