Bulk rheology of sticky DNA-functionalized emulsions

Stoev, Iliya D.; Caciagli, Alessio; Mukhopadhyay, Anasua; Ness, Christopher; Eiser, Erika

doi:10.1103/physreve.104.054602

Cited by 3 publications

(2 citation statements)

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“…The melting temperature above which the double helix is reversibly disassembled is therefore mostly controlled by the size of the sequence and the concentration of salts in solution. The bulk mechanical properties of these systems have been probed through rheology experiments [67]. Similarly to [36], they reveal that below jamming the presence of adhesion between the droplets tends to shift the rheological properties of the system from a viscous to an elastic behavior as the attraction increases by increasing binder concentration.…”

Section: Biomimetic Systems Of Adhesive Tissuesmentioning

confidence: 99%

Adhesion regulation and the control of cellular rearrangements: From emulsions to developing tissues

2022

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Cell rearrangements are critical for tissue remodeling during diverse biological processes, such as morphogenesis or cancer progression. They control tissue fluidity and can lead to irreversible shape changes in cohesive tissues. However, the completion of such rearrangements is strongly conditioned by intercellular adhesion, that can prevent their completion or conversely promote them along a given pattern. In this review we explore how intercellular adhesion impacts cell rearrangements at the local scale and how it translates into macroscopic mechanical properties in biological tissues. We first describe general principles obtained from the study of dispersed materials, such as emulsions, in which the mechanical properties and interaction potential between individual particles can be described in a quantitative manner. We then review the effect of varying cell-cell adhesion on rearrangements in vitro model tissues, from cell aggregates to 2D epithelial-like cellular layers. We finally consider developing tissues in which adhesion between the cells is strongly tuned and localized in order to allow for function and shape emergence in the embryo.

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Section: Biomimetic Systems Of Adhesive Tissuesmentioning

confidence: 99%

Adhesion regulation and the control of cellular rearrangements: From emulsions to developing tissues

2022

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“…The patchiness results from the fact that the linkers can diffuse on the surface of the droplets, and can be recruited into patches, giving rise to defined valency. We cite some relevant literature for the readers interested in DNA coated droplets [ 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. It is also worth mentioning here that, as a strategy, self-assembly is largely confined to nano/micro size components.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembly of DNA-Grafted Colloids: A Review of Challenges

et al. 2022

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DNA-mediated self-assembly of colloids has emerged as a powerful tool to assemble the materials of prescribed structure and properties. The uniqueness of the approach lies in the sequence-specific, thermo-reversible hybridization of the DNA-strands based on Watson–Crick base pairing. Grafting particles with DNA strands, thus, results into building blocks that are fully programmable, and can, in principle, be assembled into any desired structure. There are, however, impediments that hinder the DNA-grafted particles from realizing their full potential, as building blocks, for programmable self-assembly. In this short review, we focus on these challenges and highlight the research around tackling these challenges.

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