Bulimia nervosa and polycystic ovary syndrome

Jahanfar, Shayesteh; Eden, John; Nguyent, T. V.

doi:10.3109/09513599509160199

Cited by 47 publications

(33 citation statements)

References 19 publications

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“…PCOS patients also have a greater craving for sweets and there have been reports of an increased occurrence of bulimia nervosa in these women 5 . Conversely, the prevalence of polycystic ovaries is high among women with bulimia nervosa 6,7 . The mechanisms underlying these changes in eating behavior in PCOS patients are not well understood.…”

Section: Introductionmentioning

confidence: 90%

Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome

Hirschberg

Naessén

Stridsberg

et al. 2004

Gynecological Endocrinology

111

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Increased amount of abdominal fat and obesity are common in polycystic ovary syndrome (PCOS). A higher prevalence of bulimia nervosa and greater cravings for sweets have also been reported in these patients. The present study aimed to compare meal-related appetite and secretion of the 'satiety peptide' cholecystokinin (CCK) and glucose regulatory hormones in PCOS women and controls. Sixteen pairs of women with PCOS and controls matched for age and body mass index participated in the study. After an overnight fast, blood samples were collected during ingestion of a standardized meal. We determined basal and postprandial blood levels of CCK, insulin, C-peptide, glucagon, cortisol, growth hormone and glucose. Self-ratings of appetite were assessed by a visual analog scale. PCOS women had a significantly lower meal-related CCK response (p < 0.05) with no association with satiety, as in the controls (r = 0.64). There was a tendency to higher ratings of craving for sweets in PCOS women (p = 0.07) but no correlation with insulin, as in the controls (r = 0.50). Within the PCOS group, ratings of craving for sweets were inversely related to testosterone (r = - 0.60) and the CCK response was positively correlated with levels of free testosterone (r = 0.50). We conclude that women with PCOS have reduced postprandial CCK secretion and deranged appetite regulation associated with increased levels of testosterone. Impaired CCK secretion may play a role in the greater frequency of binge eating and overweight in women with PCOS.

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Section: Introductionmentioning

confidence: 90%

Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome

Hirschberg

Naessén

Stridsberg

et al. 2004

Gynecological Endocrinology

111

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“…Women with PCOS have been observed to often suffer from eating disorders, especially bulimia. 37,38 Dieting in order to lose weight is a strong risk factor for eating disorders. 39 Because overweight from adolescence into adulthood is associated strongly with symptoms of PCOS, and because weight-loss attempts are related to overweight and obesity more often than to normal weight, it is possible that eating disorders related to PCOS are a consequence of failures in weight control rather than an independent risk factor for PCOS.…”

Section: 26mentioning

confidence: 99%

Body size from birth to adulthood as a predictor of self-reported polycystic ovary syndrome symptoms

et al. 2003

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OBJECTIVE:To study the association between body size from birth to adulthood and self-reported symptoms of polycystic ovary syndrome (PCOS), particularly hirsutism and menstrual disturbances. DESIGN: Longitudinal, population-based study of a cohort of women born in 1966 in northern Finland. The study population included 2007 women who were not pregnant and did not use hormonal contraception. Of these 528 (26%) had self-reported symptoms of PCOS. RESULTS: Weight at birth, gestational age, being small for gestational age or growth retardation at birth were not associated with PCOS symptoms at 31 y. An increased risk of PCOS symptoms was observed among women with abdominal obesity (waist/ hip ratio 485th percentile) at 31 y who had normal weight in adolescence and were overweight (body mass index (BMI) 25.0-29.9 kg/m 2 ) or obese (BMI430.0 kg/m 2 ) at 31 y (relative risk (RR) (95% CI) 1.44(1.10-1.89)), and among women with abdominal obesity who were overweight or obese at both 14 and 31 y (1.71 (1.30-2.24)). A total of 30% and 41% of the women with PCOS symptoms in these groups could be attributed, respectively, to overweight, obesity and abdominal obesity at 31 y. CONCLUSIONS: These results suggest that obesity in adolescence and in adulthood, and also weight gain after adolescence, particularly in the presence of abdominal obesity, are associated with self-reported PCOS symptoms in adulthood. Thus, based on the results from intervention studies treating PCOS and the results of this study, the prevention of obesity and abdominal obesity is important among young women.

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“…Eating attitudes might also be affected in women with PCOS, and it has been suggested that high androgen levels and polycystic ovaries might advance bulimic behavior by influencing food cravings and impulse control [15]. An increased frequency of PCOS among bulimic [16] and anorectic [17] women has been reported, although these associations have been questioned [18].…”

Section: Introductionmentioning

confidence: 96%

Dietary intake, resting energy expenditure, and eating behavior in women with and without polycystic ovary syndrome

et al. 2016

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Bulimia nervosa and polycystic ovary syndrome

Cited by 47 publications

References 19 publications

Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome

Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome

Body size from birth to adulthood as a predictor of self-reported polycystic ovary syndrome symptoms

Dietary intake, resting energy expenditure, and eating behavior in women with and without polycystic ovary syndrome

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