Building trust and diversity in patient-centered oncology clinical trials: An integrated model

Hurd, Thelma C.; Kaplan, Charles D.; Cook, Elise D.; Chilton, Janice A.; Lytton, Jay; Hawk, Ernest T.; Jones, Lovell A.

doi:10.1177/1740774516688860

Cited by 22 publications

(25 citation statements)

References 52 publications

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“…The model views interpersonal trust as a changeable construct over time that involves development of the relationship, not a static trait (20). The strength of bonding and motives of linking both parties in the relationship develop from a lower base of trust into higher bases (43). In general, however, the concept of transformation in trust is found rarely from the literature in healthcare contexts, let alone the subfield of measuring trust.…”

Section: Resultsmentioning

confidence: 99%

Trust in dentist‐patient relationships: mapping the relevant concepts

Song

Luzzi

Brennan

2020

European J Oral Sciences

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Trust has a central role in healthcare encounters. This review explored concepts relevant to trust in dentist‐patient relationships. The findings were demonstrated by drawing visual system maps for better understanding of the inherent complexity. A pragmatic approach was employed to search for evidence. The approach was initiated with a systematised searching protocol and followed by an iterative process of drawing maps and complementing references. The analysis‐synthesis process found relevant key concepts and sub‐concepts presented within three frameworks: the continuum of studying trust (utilisation, measurement, and establishment); beneficiaries of trust utilisation (patients, dentists, and oral health system); and a transformational model of trust development (identification‐based, knowledge‐based, and deterrence/calculus‐based trust). Trust in dentist‐patient relationships needs to be assessed in a multidisciplinary approach for interconnectedness among relevant concepts. The findings are represented in patient‐centred care and quality of care with common underlying values. Despite the centrality of trust in medical/dental contexts, empirical evidence is insufficient beyond normative suggestions from previous studies. Based on the implications of thematic analysis and interpretation of the system maps, this paper can serve as a guide and source of information for further research of trust in dentist‐patient relationships.

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Section: Resultsmentioning

confidence: 99%

Trust in dentist‐patient relationships: mapping the relevant concepts

Song

Luzzi

Brennan

2020

European J Oral Sciences

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“…For parents who have mistrust in medical researchers, particularly African American parents, they should be provided the following information: (1) details on the medical researcher and their role in the research process; (2) the benefits of their child participation in the clinical trial, (benefits to their child and other children); and (3) the risks of participation in medical research (including disruptions to their daily routine) and assurance that their child will not be treated as a guinea pig. Based on previous literature (Holzer, Ellis, & Merritt, 2014;Hurd et al 2017;McDavitt et al, 2016), intervention strategies that could be used to provide this information include application of community engaged approaches, message tailoring, and use of testimonials. These communication strategies are key to building trust among underrepresented populations in research, and could assist in building trust between parents and researchers.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing parental trust in medical researchers for child and adolescent patients’ clinical trial participation

Cunningham-Erves

Deakings

Mayo-Gamble

et al. 2019

Psychology, Health & Medicine

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Parental trust in medical researchers is a commonly cited barrier to their child's participation in clinical research. Yet, there is little understanding of factors influencing parental trust to be implemented in interventions to address their concerns. This study seeks to identify psychosocial and modifying factors influencing parental trust in medical researchers to improve child and adolescent patients clinical trial participation, and potentially their health outcomes. We conducted a cross-sectional study with 307 parents. Multiple ordinary linear (OLS) regression was conducted to determine: (1) psychosocial and modifying factors associated with parental trust; and (2) perceived advantages and disadvantages associated with parental trust. Parent's race (White) (β=. 343, p<.001), higher education level (β=.409, p<.001), higher perceived advantages of adolescent clinical trials (β=.142, p<.001), and lower perceived disadvantages of adolescent clinical trials (β= −.337, p=.001) were the most significant predictors of higher levels of parental trust in medical researchers. Parents who were African American and had lower education levels expressed lower levels of trust in medical researchers. Education on the benefits of clinical trials could reduce parents' apprehension towards their child's participation in clinical trials. Results support the

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“…An extremely robust and culturally confident team was engaged in PREVAIL to address social fears and stigma. Building trust would be critical, as noted in Hurd et al, “Trust is the cornerstone of clinical trial recruitment and retention.’ [ 4 ].…”

Section: The Myths and The Challengesmentioning

confidence: 99%

A review of strategies used to retain participants in clinical research during an infectious disease outbreak: The PREVAIL I Ebola vaccine trial experience

Browne

Carter

Eckes

et al. 2018

Contemporary Clinical Trials Communications

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IntroductionThis article describes a retrospective review of participant follow-up and retention strategies in the Partnership for Research on the Ebola Virus in Liberia (PREVAIL) I Vaccine Trial. It illustrates and analyzes strategies used to retain participants in an emergency clinical research response vaccine trial conducted during the 2014 Ebola outbreak in Liberia.MethodsAn anecdotal review of participant retention strategies developed and employed during the PREVAIL I vaccine trial.ResultsThough other factors likely contributed to the high retention rate of trial participants, the unique PREVAIL I follow-up process described resulted in an exceptionally high participant retention rate (97.8%) through 12 months of follow-up, increased the ability to obtain meaningful trial results, and provided a platform through which to respond to social issues in an emergency clinical research response setting.ConclusionSuccessful strategies were developed and employed in the PREVAIL I vaccine trial that resulted in extraordinarily high participant retention and follow-up rates during an infectious disease outbreak. This review illustrates that employing host country social mobilization concepts within a modified clinical research management framework is highly correlated to elevated rates of retention and minimal loss to follow-up. These strategies also contributed to increased data quality and enhanced adherence to protocol requirements. The increased ability to respond to social issues such as stigma, job retention and relationship conflicts was an additional and significant benefit of this follow-up methodology.

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Building trust and diversity in patient-centered oncology clinical trials: An integrated model

Cited by 22 publications

References 52 publications

Trust in dentist‐patient relationships: mapping the relevant concepts

Trust in dentist‐patient relationships: mapping the relevant concepts

Factors influencing parental trust in medical researchers for child and adolescent patients’ clinical trial participation

A review of strategies used to retain participants in clinical research during an infectious disease outbreak: The PREVAIL I Ebola vaccine trial experience

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