Online learning makes great demands, including in terms of selfregulated learning. Self-regulated learning in terms of using learning resources to find solutions to learning problems in terms of concept discovery and problem-solving of their own learning patterns. This is related to the concept of self-knowledge in the scope of metacognitive abilities in information processing involving neuroscience studies. Descriptions of self-regulated learning and metacognitive abilities were obtained through a literature study as well as analysis of the results of interviews and filling out questionnaires that had been carried out in previous research on the neuroscience studies in self-regulated learning for science teacher candidates through optimizing the Learning Management System (LMS) with the SPADA feature. The results of the study that explain the involvement of self-regulated learning and metacognitive abilities in neuroscience are used as a basis for further research related to learning innovations which are absolutely necessary in conducting in-depth studies on this subject.