The numerical results of mathematical modeling of a two-phase, axisymmetric swirling turbulent flow in the separation zone of a centrifugal separator are presented. The movement of the carrier gas flow was modeled using RANS, which were closed using the SARC turbulence models, the SST-RC model, and the SSG/LRR-RSM-w2012 model. For the numerical solution of the problem, the SIMPLE algorithm was used. The article compares the results of numerical calculation of turbulence models. The results of a comparison of numerical calculations with allowance for the effect of the solid phase on the dynamics of the air medium and without taking it into account with experimental data are presented.