Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model

Yang, Xue; Ding, Tiexin; Mao, Mengting; Zhu, Shengbo; Zhou, Jianhong; Zhang, Lan; Han, Yong

doi:10.1016/j.bioactmat.2021.06.029

Cited by 20 publications

(25 citation statements)

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“…During the PTT, photo-responsive agents increase local temperature rapidly under NIR irradiation, stimulating cells, or killing bacteria. Many kinds of agents such as noble metals, [23] red and black phosphorus, [24,25] metal sulfides, [26] and metallic oxides [27] have been applied in PTT, however, they are mostly in the form of powders. Even though they can be loaded on the implant surfaces, their persistence and metabolism process in vivo need to be settled.…”

Section: Introductionmentioning

confidence: 99%

Surface Bandgap Engineering of Nanostructured Implants for Rapid Photothermal Ion Therapy of Bone Defects

Yang

Zhang

Liu

et al. 2022

Adv Healthcare Materials

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Bone defects are seriously threatening the health of orthopedics patients and it is difficult for implants to accelerate bone regeneration without using bone growth factors. Herein, a fast photothermal ion therapeutic strategy is developed based on the bandgap engineering of nanostructured TiO 2 through (Si/P)-dual elemental doping by micro-arc oxidation treatment of titanium implants. The (Si/P)-dual doping can tune the surface bandgap structure of TiO 2 by decreasing bandgap and broadening valence band simultaneously, which is confirmed by density functional theory calculations. It not only endows the implants with a mildly photothermal effect under near-infrared (NIR) light irradiation, but also creates an (Si/P) ion-rich microenvironment around the implants. This photothermal ion microenvironment can tune the behaviors of osteoblasts by promoting p38/Smad and ERK signaling pathways of osteoblasts, thus significantly upregulating the expression of osteogenesis genes by the synergistic action of mild photothermal stimulation and increased release of Si/P ions. The in vivo results are also in good agreement with in vitro tests, i.e., under NIR light irradiation, the photothermally responsive TiO 2 enhances the bone formation and osteointegration with implants. Therefore, this kind of photothermal ion strategy is a promising remote and noninvasive therapeutic mode for promoting bone regeneration of Ti implants.

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Section: Introductionmentioning

confidence: 99%

Surface Bandgap Engineering of Nanostructured Implants for Rapid Photothermal Ion Therapy of Bone Defects

Yang

Zhang

Liu

et al. 2022

Adv Healthcare Materials

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“…A weakly alkaline microenvironment, with pH value of 8.0−8.5, upregulates AMPK and stimulates proliferation and differentiation of osteoblasts, facilitating bone formation. 51,52 For pH levels of culture medium with different samples (Figure 4h), they initially increased to about pH 8.3 after 1 day of immersion and then almost remain unchanged at about pH 8.5, suggesting that the increased pH levels induced by the samples should improve osteoblast behaviors.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Surface nanotopography (e.g., nanorods) simulating natural ECM has been explored to improve response of osteogenesis-related cells in our previous studies. − ,, Col-I is the main organic component of natural extracellular matrices and provides a number of important nutrients, enabling it to be mineralized to bone during the tissue regeneration . With the combined action of lower Zn 2+ concentration, an additional supplement of Si, nanorod-like topography, and Col-I, ZC had more improved adhesion, proliferation, and differentiation of osteoblasts compared with ZS and ZN (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Compared with ZN, ZC and ZS had lower Zn 2+ and additional Si. Zn 2+ has been reported to promote endothelial cell proliferation and differentiation by stimulating the expression of endothelium-related factors . Si ions can stimulate the high expression of VEGF in HUVECs and then activate KDR to initiate the angiogenic pathway .…”

Section: Resultsmentioning

confidence: 99%

“…Zn 2+ has been reported to promote endothelial cell proliferation and differentiation by stimulating the expression of endothelium-related factors. 51 Si ions can stimulate the high expression of VEGF in HUVECs and then activate KDR to initiate the angiogenic pathway. 52 In addition, ZC has additionally sustained release of Col-I in the extract media (Figure S3), further improving the behavior of endothelial cells.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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An Extracellular Matrix-like Surface for Zn Alloy to Enhance Bone Regeneration

Mao

Zhu

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Zn-based alloys are promising biodegradable implants for bone defect repair due to their good mechanical performance and degradability. However, local Zn2+ released from Zn-based implants can seriously affect adhering cell behaviors as well as new bone formation on implant surfaces. To address this issue, we have fabricated a bone-mimetic extracellular matrix (ECM)-like surface on Zn-1Ca implants using a hybrid process of anodization, hydrothermal treatment (HT), and fluorous-curing. The ECM-like surface consisted of Zn2SiO4 nanorods layered with collagen I (Col-I). The Zn2SiO4 nanorods were hemicrystallized and transformed by the reaction of Zn(OH)2 and SiO4 4– during the HT. The Zn2SiO4 nanorods effectively protected the substrate from corrosion; the Col-I layer decreased the degradation of Zn2SiO4 nanorods and further reduced Zn2+ release into the medium. This ECM-like surface generated a microenvironment with appropriate Zn2+ levels, nanorod-like topography, and Col-I. It significantly improved adhesion, proliferation, and differentiation of osteoblasts on implant surfaces and vascularization of endothelial cells in the extract medium. The in vivo results are in good agreement with in vitro tests, with the ECM-like surface significantly enhancing new bone formation and bone-implant contact compared to the bare implant surface. Overall, this bone-mimetic ECM-like material of Col-I layered Zn2SiO4 nanorods is a promising scaffold that promotes the bone regeneration of Zn-based implants.

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