Building and validating trend-based multiple sclerosis case definitions: a population-based cohort study for Manitoba, Canada
Naomi C Hamm,
Ruth Ann Marrie,
Depeng Jiang
et al.
Abstract:ObjectiveThis study aims to (1) build and validate model-based case definitions for multiple sclerosis (MS) that use trends (ie, trend-based case definitions) and (2) to apply dynamic classification to identify the average number of data years needed for classification (ie, average trend needed).DesignRetrospective cohort study design.Participants608 MS cases and 59 620 MS non-cases.SettingData from 1 April 2004 to 31 March 2022 were obtained from the Manitoba Population Research Data Repository. MS case statu… Show more
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