Building and behavior of a pH-stimuli responsive chitosan nanoparticles loaded with folic acid conjugated gemcitabine silver colloids in MDA-MB-453 metastatic breast cancer cell line and pharmacokinetics in rats

Karuppaiah, Arjunan; Babu, Dinesh; Selvaraj, Divakar; Tamilselvan, Natarajan; Rajan, Ravikumar; Gautam, Mrinmoy; Hariprasad, Ranganathan; Karthik, S.; Nesamony, Jerry; Sankar, Veintramuthu

doi:10.1016/j.ejps.2021.105938

Cited by 12 publications

(3 citation statements)

References 43 publications

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“…The encapsulation efficiency (EE) of GEM separated by dialysis was determined using a UV spectrophotometer [ 35 ]. The liposome was added into the dialysis bag (MWCO 8.0–14.0 kDa), which was immersed in PBS and stirred slowly for 4 h to completely remove the free GEM.…”

Section: Methodsmentioning

confidence: 99%

Efficient Delivery of Gemcitabine by Estrogen Receptor-Targeted PEGylated Liposome and Its Anti-Lung Cancer Activity In Vivo and In Vitro

et al. 2023

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Lung cancer is one of the main causes of cancer-related deaths. At present, the main treatment method for lung cancer is chemotherapy. Gemcitabine (GEM) is widely applied in lung cancer treatment, but its lack of targeting ability and serious side effects limit its application. In recent years, nanocarriers have become the focus of research to solve the above problems. Here, we prepared estrone (ES)-modified GEM-loaded PEGylated liposomes (ES-SSL-GEM) for enhanced delivery by identifying the overexpressed estrogen receptor (ER) on lung cancer A549 cells. We studied the characterization, stability, release behavior, cytotoxicity, targeting ability, endocytosis mechanism, and antitumor ability to prove the therapeutic effect of ES-SSL-GEM. The results showed that ES-SSL-GEM presented a uniform particle size of 131.20 ± 0.62 nm, a good stability, and a slowly released behavior. Moreover, ES-SSL-GEM enhanced tumor-targeting ability, and the endocytosis mechanism studies confirmed that the ER-mediated endocytosis had the most crucial effect. Furthermore, ES-SSL-GEM had the best inhibitory effect on A549 cell proliferation and significantly suppressed the tumor growth in vivo. These results suggest that ES-SSL-GEM is a promising agent for treating lung cancer.

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Section: Methodsmentioning

confidence: 99%

Efficient Delivery of Gemcitabine by Estrogen Receptor-Targeted PEGylated Liposome and Its Anti-Lung Cancer Activity In Vivo and In Vitro

et al. 2023

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“…Regarding the present study, a wide range of patterns can be created in a single step, which is more effective compared to conventional lithography [21], and, moreover, it is cheaper. When optimizing the formation of the reverse pyramid in thin ultramicrotome cut of the polymer, one can effectively prepare nanoporous membranes [27]. Thereafter, stimuli-responsive membranes can be produced by subsequent ligandization of anchored AgNPs.…”

Section: Samplementioning

confidence: 99%

“…Together with the stimuli-responsive ability of the ligands, it can be utilized for the control and monitoring of transport properties of membranes. For functionalization, several strategies have been developed based on chemical procedures [27]. Taking into account the strong bond [19] formed between nanoparticles and material, optomechanical manipulation is one of the promising ways to plainly anchor such ligandized NPs on the walls of pores.…”

Section: Introductionmentioning

confidence: 99%

Decoration of Ultramicrotome-Cut Polymers with Silver Nanoparticles: Effect of Post-Deposition Laser Treatment

et al. 2022

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Today, ultramicrotome cutting is a practical tool, which is frequently applied in the preparation of thin polymeric films. One of the advantages of such a technique is the decrease in surface roughness, which enables an effective recording of further morphological changes of polymeric surfaces during their processing. In view of this, we report on ultramicrotome-cut polymers (PET, PEEK) modified by a KrF excimer laser with simultaneous decoration by AgNPs. The samples were immersed into AgNP colloid, in which they were exposed to polarized laser light. As a result, both polymers changed their surface morphology while simultaneously being decorated with AgNPs. KrF laser irradiation of the samples resulted in the formation of ripple-like structures on the surface of PET and worm-like ones in the case of PEEK. Both polymers were homogeneously covered by AgNPs. The selected area of the samples was then irradiated by a violet semiconductor laser from the confocal laser scanning microscope with direct control of the irradiated area. Various techniques, such as AFM, FEGSEM, and CLSM were used to visualize the irradiated area. After irradiation, the reverse pyramid was formed for both types of polymers. PET samples exhibited thicker transparent reverse pyramids, whereas PEEK samples showed thinner brownish ones. We believe that his technique can be effectively used for direct polymer writing or the preparation of stimuli-responsive nanoporous membranes.

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Recent Progression in Controlled Drug Delivery Through Advanced Functional Nanomaterials in Cancer Therapy

Deb,

Chauhan,

Chandra

et al. 2024

BioNanoSci.

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Building and behavior of a pH-stimuli responsive chitosan nanoparticles loaded with folic acid conjugated gemcitabine silver colloids in MDA-MB-453 metastatic breast cancer cell line and pharmacokinetics in rats

Cited by 12 publications

References 43 publications

Efficient Delivery of Gemcitabine by Estrogen Receptor-Targeted PEGylated Liposome and Its Anti-Lung Cancer Activity In Vivo and In Vitro

Efficient Delivery of Gemcitabine by Estrogen Receptor-Targeted PEGylated Liposome and Its Anti-Lung Cancer Activity In Vivo and In Vitro

Decoration of Ultramicrotome-Cut Polymers with Silver Nanoparticles: Effect of Post-Deposition Laser Treatment

Recent Progression in Controlled Drug Delivery Through Advanced Functional Nanomaterials in Cancer Therapy

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