The working of this paper focuses on the matching relationship of operating mode and profiting mode to interorganizational information systems(IOS) to help to make a decision on how to choose or build an IOS to IOS' users and provider. Firstly, this paper builds a theoretical matching model on operating mode and profiting mode to IOS; and then examines the relationship of factors of operating and profiting in practice to figure out the matching characteristics; lastly, prompts to a expected dynamic optimal profit model to reflect the matching mechanism.