Buflomedil

Norepinephrine, Phentolamine and Buflomedil Influence on Arteriolar Vasomotion in the Hamster Skinfold Preparation

“…Arteriolar vasomotion, a physiological phenomenon that has been found in most tissues [1][2][3][4], plays an important role in the local regulation of capillary rheology, flow and fluid exchange [1,5,6]. The basic mech anism of this phenomenon is thought to be myogenic, but it has been shown that cate cholamines can influence vasomotion be havior, the main effect being an increase in frequency [7], The vasoactive compound buflomedil has documented nonspecific alpha-adrenergicblocking properties [8][9][10], By contrast, this drug has also been shown capable of restor ing vasomotion after on purpose depression of this activity by administration of phéno barbital [11].The aims of this study were to investi gate further the influence of alpha-adrener gic receptors activation and blockade on ar teriolar vasomotion and to assess the hy pothesis of an alpha-adrenergic-mediated in fluence of buflomedil on the vasomotion phenomenon. …”