Buffering effect of antacids in the mouth ‐ a new treatment of dental erosion?

Meurman, Jukka H.; Kuittinen, T.; Kangas, Marjaana; Tuisku, T.

doi:10.1111/j.1600-0722.1988.tb01576.x

Cited by 12 publications

(14 citation statements)

References 7 publications

(3 reference statements)

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“…Volunteers used a series of two min oral rinses after each one min HCl rinse (to mimic the pH of acid reflux) and the acid: base balance in the mouth was followed for 30 min. There was no mention of irritation or other effects of any of the solutions, but overall the results with Al(OH) 3 were consistent with those of Meurman et al (1988) who found chewing an Al(OH) 3 tablet was an effective means to combat dental softening and erosion due to chronic acid regurgitation.…”

Section: Digestive Tractsupporting

confidence: 80%

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

332

201

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Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability.Address for correspondence: Calvin C. Willhite, Risk Sciences International, 55 Metcalfe Street, Suite 700, Ottawa, ON, Canada. calvinwillhite@hotmail.com. Declaration of interestPartial funding for this work was provided by a contract to review the recent scientific literature on health effects of aluminum between the International Aluminium Institute (IAI, www.world-aluminium.org), the Aluminium Reach Consortium (ARC, www.aluminium-reach-consortium.eu), and Risk Sciences International (RSI, www.risksciences.com), a Canadian company established in 2006 in partnership with the University of Ottawa. Additional financial support was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) to D. Krewski, who holds the NSERC Chair in Risk Science at the University of Ottawa. C.C. Willhite, N.A. Karyakina, F. Momoli, and N. Yenugadhati were compensated by RSI for their contributions to the review. I. Arnold, T. Wisniewski and R. Yokel received no compensation from RSI for their contributions to this work. The authors, whose affiliations are shown on the title page, had sole responsibility for preparation of this paper, including determining the strategy for reviewing the scientific literature summarized in this article, synthesizing the findings, and drawing conclusions. Scientists associated with IAI/ARC were given the opportunity to review and offer technical comments on the paper, prior to submission to Critical Reviews in Toxicology. I. Arnold serves as a consultant to the International Aluminium Institute. None of the authors have appeared before regulatory agencies on behalf of the sponsors, or appeared as experts in legal proceedings concerning matters reviewed in this paper. The scientific opinions and conclusions expressed in the paper are exclusively those of the authors, and are independent of the sources of financial support. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptThe present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007). The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances.

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Section: Digestive Tractsupporting

confidence: 80%

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

332

201

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“…These have a more limited clinical effect in dental erosion [129–136], even if their positive effect in the prevention of dental caries is well established. The use of neutralizing products such as antacid drugs has been shown to increase intraoral pH after an acidic challenge [137, 138], while rinsing with bicarbonate decreased tooth surface loss after artificially induced erosion, it did not alter surface microhardness [139]. A large variety of dental care products for prevention of dental erosion is on the market but there is no formula or product available today that provides adequate protection against erosion [140].…”

Section: Clinical Aspectsmentioning

confidence: 99%

Dental Erosion and Its Growing Importance in Clinical Practice: From Past to Present

Johansson

Omar

Carlsson

et al. 2012

International Journal of Dentistry

145

114

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Since the mid-1990s, the focus of studies on tooth wear has steadily shifted from the general condition towards the more specific area of dental erosion; equally, a shift has occurred from studies in adults to those in children and adolescents. During this time, understanding of the condition has increased greatly. This paper attempts to provide a critical overview of the development of this body of knowledge, from earlier perceptions to the present. It is accepted that dental erosion has a multifactorial background, in which individual and lifestyle factors have great significance. Notwithstanding methodological differences across studies, data from many countries confirm that dental erosion is common in children and young people, and that, when present, it progresses rapidly. That the condition, and its ramifications, warrants serious consideration in clinical dentistry, is clear. It is important for the oral healthcare team to be able to recognize its early signs and symptoms and to understand its pathogenesis. Preventive strategies are essential ingredients in the management of patients with dental erosion. When necessary, treatment aimed at correcting or improving its effects might best be of a minimally invasive nature. Still, there remains a need for further research to forge better understanding of the subject.

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“…3,4 Such measures include the use of antacids, 5 fluorides 6 and oral hygiene practices. Even though fluoride has been successfully used to inhibit dental caries, its availability through dietary fluoride supplementation programmes or through regular use of fluoridated dentifrices does not appear to result in teeth being more resistant to erosion.…”

mentioning

confidence: 99%

Studies on dental erosion: An in vivo‐in vitro model of endogenous dental erosion‐its application to testing protection b flouride gel application

Jones¹,

Lekkas²,

Hunt³

et al. 2002

Australian Dental Journal

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Background:The objective in this study was to develop an in vivo-in vitro model of endogenous erosion, with a view to exploring the potential for some degree of its control by the use of topical fluoride gel application to teeth. Methods: Six volunteers each wore a small clasp retained palatal acrylic appliance to which six sterilized enamel tiles were bonded. Three tiles on each appliance were coated extra-orally with either 1.23 per cent acidulated phosphate fluoride (APF) or 2.2 per cent sodium fluoride (NaF) neutral gel for four minutes prior to multiple periods of exposure to the simulated gastric acid, cumulating in 16, 36, 80 and 150 minutes of exposure. Impressions of the enamel tiles prior to and following acid exposure permitted dies to be prepared. These were sectioned through the exposed areas and examined under a stereomicroscope to assess maximum depths of erosion. Results: The depth of erosive demineralization of enamel was found to be greatly reduced with increased frequency of APF gel application. The reduction in enamel loss was less following topical application of NaF gel. Conclusions: It was concluded that fluoride gels significantly reduced enamel erosion using this in vivo-in vitro model and therefore, if prescribed appropriately, should help reduce tooth tissue loss from endogenous erosion.

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Buffering effect of antacids in the mouth ‐ a new treatment of dental erosion?

Cited by 12 publications

References 7 publications

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Dental Erosion and Its Growing Importance in Clinical Practice: From Past to Present

Studies on dental erosion: An in vivo‐in vitro model of endogenous dental erosion‐its application to testing protection b flouride gel application

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