Go to 4 4. Obtain information on the toxicity of the active ingredient to surrogate mammals and birds, including data from the human health assessment. The test results should generally cover (see Note 2): -acute oral LD50 and NOEC from chronic feeding studies on rats; -acute oral LDSO for two bird species, and dietary toxicity for one bird; -additional data on irritancy, reproductive toxicity, etc., if available.Environmental f a t eQuestions 5-1 1 deal with the distribution and persistence of the active ingredient in the environment after its application. Products are regarded as falling into three main kinds: (a) sprays, (b) treated items such as pellets, granules and coated seeds', (c) baits other than pellets such as rodenticides.' In this scheme, the term 'pellet' is used for a formulation in which an active ingredient is mixed with a nutritious base (e.g. cereal) (in GIFAP terminology this a 'granular bait'); the term 'coated seed' (='pill' in Dutch terminology) is used for a formulation with one or a series of coatings around a seed as a core (in GIFAP terminology this is a 'seed coated with a pesticide'); the term granule is used in the GIFAP sense.