Ultra-cold RbCs molecules in high-lying vibrational levels of the a 3 Σ + ground electronic state are confined in an optical trap. Inelastic collision rates of these molecules with both Rb and Cs atoms are determined for individual vibrational levels, across an order of magnitude of binding energies. A simple model for the collision process is shown to accurately reproduce the observed scattering rates.The electric dipole-dipole interaction provides a longrange, tunable anisotropic interaction between polar molecules. This is fundamentally different from most interactions studied between ultra-cold atoms, which are typically isotropic and comparatively short-ranged. Features of the dipole-dipole interaction can lead to many novel and exciting phenomena, such as field-linked states [1], long-range topological order [2], quantum chemistry [3,4], and the possibility for quantum computation [5,6]. Furthermore, the presence of closely spaced internal levels of the molecules, e.g. Ω-doublet, rotational, and vibrational levels, presents a host of new possibilities for precision measurement of fundamental physics [7,8,9,10,11]. Producing ultra-cold samples of polar molecules will facilitate trapping and, thus, the required high densities and long observation times for observing these phenomena.Techniques such as Stark deceleration [12] and buffer gas cooling [13] are capable of producing cold samples from a wide range of molecular species; however, the temperatures and densities currently attainable via these "direct cooling" methods are not sufficient for observing many of the interesting phenomena mentioned above. Conversely, the association of ultra-cold atoms, either via a Feshbach [14] or optical resonance [15], restricts experiments to a limited class of molecules -namely, those composed of laser cooled atoms. Nonetheless, these methods are approaching temperatures and densities appropriate for observing the aforementioned phenomena.In this Letter, we report the optical confinement of ultra-cold, vibrationally excited RbCs molecules in the a 3 Σ + ground electronic state, produced via photoassociation (PA) of laser-cooled 85 Rb and 133 Cs atoms. We utilize the long observation times afforded by the optical trap to determine the inelastic scattering rate for specific vibrational levels of these molecules, with both 85 Rb and 133 Cs atoms, across an order of magnitude of binding energies. We show that a simple model for the collision process accurately reproduces the observed scattering rates. We also extend this model to * Electronic address: Eric.Hudson@Yale. estimate molecule-molecule inelastic scattering rates and discuss implications for producing trapped samples of X 1 Σ(v = 0) RbCs molecules.The apparatus used in this work is shown in Fig. 1. Briefly, 85 Rb and 133 Cs atoms are cooled and collected in a dual-species, forced dark-spot magneto-optical trap (DSM) [15,16]. Using absorption imaging along two orthogonal directions we co-locate the species and measure the atomic density, n, and atom number, N , as n...