“…Condition-related costs included adverse event costs and complication costs. Seven studies only calculated treatmentrelated costs only (10,(13)(14)(15)(21)(22)(23). Eleven studies took into account both treatment-related costs and condition-related costs (11,12,(16)(17)(18)(19)(20)(24)(25)(26)(27), of which nine studies considered the cost of hypoglycemia which was further classified into minor and severe hypoglycemia (11,12,16,18,20,(24)(25)(26)(27), six studies considered the cost of diabetes-related complications (11,16,17,19,25,27) (mainly including myocardial infarction (MI), stroke, heart failure, heart disease) and only one took the cost of adverse event (including dizziness, vomiting, fatigue and loss of appetite) into account (12).…”