Budesonide induction and maintenance therapy for Crohnʼs disease during pregnancy

Abstract

Budesonide may be a safe option for treatment of CD during pregnancy.

Approach to the Management of the Pregnant Inflammatory Bowel Disease Patient: Successful Outcome

“…Budesonide has been shown to be effective for induction of remission in Crohn's disease. In a limited study using 8 patients with Crohn's disease at a dose of 6-9 mg daily there was no evidence of foetal abnormality (Beaulieu, et al 2009).…”

Treatment of inflammatory bowel disease and pregnancy: a review of the literature

“…In a metanalysis, prednisone increases to 3.4-fold the risk of oral cleft, but without major complications in therapeutic doses (45) . However, oral budesonide seems to be safe, in doses 6 to 9 mg/d, without reports of maternal adrenal suppression, glucose intolerance, ocular side effects, hypertension or fetal congenital abnormalities (3) . There seems to be no significant placental transfer of topical corticosteroids, but there is a small number of researches (28) .…”

Safety of drugs used in cases with ulcerative colitis during pregnancy and lactation

“…However, in a large scale (2968 pregnants) retrospective cohort study performed among women who had used budesonide inhalation during their pregnancies because of allergy or asthma, no increase was established in the risks for LBW, preterm labor, stillbirth, or fetal malformation (19). In a series comprising 8 CD (Crohn's disease) cases of IBD, no relationship was found between budesonide and pregnancy complications (20).…”