Budd-Chiari Syndrome

Grus, Tomáš; Lambert, Lukáš; Grusová, Gabriela; Banerjee, Rohan; Burgetová, Andrea

doi:10.14712/23362936.2017.6

Cited by 41 publications

(65 citation statements)

References 36 publications

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“…Regardless of the cause of the venous outflow obstruction, increased hepatic sinusoidal pressure and portal hypertension occur rapidly, leading to ischemic damage to the hepatocytes, followed by nodular regeneration, fibrosis, and eventually cirrhosis. In addition, large regenerative nodules may in turn lead to compression of intrahepatic veins [1,4]. This study is the first report to compare the clinical features, laboratory parameters, and outcomes between acute and chronic BCS from Iran.…”

Section: Discussionmentioning

confidence: 90%

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A study of the different parameters in acute and chronic Budd–Chiari syndrome

Niknam

Hajizadegan

Mohammadkarimi

et al. 2020

Egypt Liver Journal

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Background Budd–Chiari syndrome (BCS) is a rare and potentially life-threatening vascular disease of the liver. There are a few studies on the differences between acute and chronic BCS in clinical and laboratory characteristics, as well as the outcomes, so we designed this research to study the different parameters in acute and chronic BCS. Diagnosis of BCS was made using Doppler ultrasound, magnetic resonance imaging, and venography. Patients with BCS were then divided into chronic and acute groups based on both imaging characteristics and disease duration. Finally, the outcomes, clinical features, and laboratory parameters of acute and chronic BCS were compared. Results In total, 60 patients were included in this study, of whom 28.3% and 71.7% had acute and chronic BCS, respectively. According to clinical features, spontaneous bacterial peritonitis (PR 1.289; 95% CI 1.115–1.489; P = 0.001) and jaundice (PR 1.308; 95% CI 1.148–1.490; P < 0.001) were significantly associated with chronic than acute BCS. According to laboratory parameters, the levels of international normalized ratio (INR) (PR 0.953; 95% CI 0.918–0.989; P = 0.012), blood urea nitrogen (BUN) (PR 0.996; 95% CI 0.993–1.000; P = 0.039), and model for end-stage liver disease (MELD) score (PR 1.024; 95% CI 1.012–1.037; P < 0.001) in chronic group were significantly higher than in the acute BCS. The hospital length of stay (LOS) and mortality rate between the two groups did not differ significantly. Conclusions This study showed that the spontaneous bacterial peritonitis, jaundice, increased levels of MELD score, INR, and BUN were significantly associated with the chronic group compared with the acute group. The hospital LOS and mortality rate between the two groups did not differ significantly. Further research is recommended to clarify this issue.

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Section: Discussionmentioning

confidence: 90%

“…Budd-Chiari syndrome (BCS) is a rare and potentially life-threatening disorder caused by a partial or complete occlusion from small hepatic veins till inferior vena cava including the main hepatic veins [1][2][3]. The true incidence of BCS is unknown due to its rarity, and various results have been reported in different regions [3,4].…”

Section: Introductionmentioning

confidence: 99%

A study of the different parameters in acute and chronic Budd–Chiari syndrome

Niknam

Hajizadegan

Mohammadkarimi

et al. 2020

Egypt Liver Journal

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“…BCS is a disease complex that results from impairment of hepatic venous outflow, mostly at the level of the hepatic veins, IVC, or both [1 , 2] . BCS is rare, with an overall incidence of 0.1 to 10 cases per million people annually [1] . When untreated, BCS results in portal hypertension, cirrhosis, and liver failure that is oftentimes fatal.…”

Section: Discussionmentioning

confidence: 99%

“…When untreated, BCS results in portal hypertension, cirrhosis, and liver failure that is oftentimes fatal. If left untreated, there is a 3-year mortality of 90% [1] . If treated, patient survival can range from 42% to 100% [1] .…”

Section: Discussionmentioning

confidence: 99%

Acute Budd-Chiari syndrome during hepatic vein catheterization

Rohringer

Zaarour

Williams

et al. 2020

Radiology Case Reports

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This case report describes a 4-year-old male with a history of hepatoblastoma, treated with chemotherapy followed by a right extended hepatectomy. Secondary to this, the patient experienced recurrent hepatic vein stenosis. He was treated initially with conventional angioplasty, followed by paclitaxel-coated balloon dilatations in an attempt to prevent episodes of re-stenosis. During the catheterization of the hepatic vein in one of the treatments, hemodynamic instability due to an acute Budd-Chiari syndrome occurred. The hemodynamic compromise became unresponsive to intravascular resuscitation and inotropic support. The patient was then treated with an emergency conventional angioplasty of the hepatic vein, which resulted in a rapid response and eventually in a full recovery. The etiology of this complication remains unclear; however, it may have been secondary to endothelial damage leading to acute thrombosis and/or venous spasm. Conventional angioplasty was successful in managing this complication. Awareness of iatrogenic acute Budd-Chiari syndrome as a potentially fatal complication during hepatic catheterization/dilatation, especially in the posthepatectomy setting, successful management of this complication, and the importance of a multidisciplinary and rapid response, is emphasized.

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“…The diagnosis is established after confirming the hepatic outflow obstruction, either by ultrasonography (US), computer tomography (CT) scan or magnetic resonance imaging (MRI) [3].…”

Section: Introductionmentioning

confidence: 99%

Budd-Chiari syndrome - various etiologies and imagistic findings. A pictorial review

et al. 2019

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Budd Chiari syndrome defines an obstruction of the hepatic venous outflow. Primary causes include pro-coagulant states resulting in venous thrombosis, while secondary Budd Chiari syndrome appears in conditions associated with extrinsic compression of the hepatic veins or tumor invasion. Clinical presentation is greatly varied, from incidentally discovered asymptomatic thrombosis to fulminant liver failure due to hepatic congestion. Abdominal ultrasonography is the key diagnostic tool of Budd Chiari syndrome. This pictorial essay aims to show the ultrasonographic aspect of Budd-Chiari syndrome associated with other medical conditions (abdominal malignancy, hematologic disorders and abdominal surgery).

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Budd-Chiari Syndrome

Cited by 41 publications

References 36 publications

A study of the different parameters in acute and chronic Budd–Chiari syndrome

A study of the different parameters in acute and chronic Budd–Chiari syndrome

Acute Budd-Chiari syndrome during hepatic vein catheterization

Budd-Chiari syndrome - various etiologies and imagistic findings. A pictorial review

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