Buckwheat Concentrate Reduces Serum Glucose in Streptozotocin-Diabetic Rats

J, Kawa; Taylor, Carla G.; Przybylski, Roman

doi:10.1021/jf0302153

Cited by 140 publications

(109 citation statements)

References 17 publications

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“…Results of animal studies showed a decreasing effect of DCI on glucose concentration in blood of streptozocin-induced rats [Kawa et al, 2003] and blood pressure, plasma triglyceride and glucose concentrations in type 2 diabetic mice [Yao et al, 2008]. Moreover, the important role of DCI glycans as a second messenger in insulin abnormal response was explained by Larner et al [2010].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs)

Przygodzka¹,

Zieliński²

2015

Pol. J. Food Nutr. Sci.

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In this study, the relationship between the inhibitory effects of extracts from rye-buckwheat ginger cakes supplemented with low and high rutin dosage baked without or with dough fermentation step on the formation of fluorescent advanced glycation end-products (AGEs), and phenolic compounds, rutin, D-chiro-inositol and antioxidant capacity were addressed. The cakes were based on rye flour substituted by light buckwheat flour or flour from roasted buckwheat groats at 30% level, and were produced with or without dough fermentation step. The inhibitory effect against AGEs formation was studied in bovine serum albumin (BSA)-glucose and BSA-methylglyoxal (MGO) systems. The antioxidant capacity was measured by 2,2-diphenyl--1-picrylhydrazyl (DPPH) and cyclic voltammetry (CV), rutin and D-chiro-inositol contents by HPLC and total phenolics (TPC) by spectrophotometric assays. The study showed the inhibitory effects of extracts from rye-buckwheat ginger cakes supplemented with low and high rutin dosage. The results of the inhibitory activity were highly correlated in two applied model systems. Enrichment of rye-buckwheat ginger cakes with rutin improved their antioxidant properties. The correlation studies showed that the inhibitory effects of rye-buckwheat ginger cakes produced with dough fermentation step and enhanced with rutin against formation of AGEs were highly correlated with TPC, rutin and D-chiro-inositol contents, and antioxidant capacity. Moreover, the effect of rutin enrichment was clearly seen in cakes obtained with dough fermentation step, even the inhibitory activity was slightly lower as compared to the cakes produced without dough fermentation.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs)

Przygodzka¹,

Zieliński²

2015

Pol. J. Food Nutr. Sci.

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“…Some of these derivatives have been reported to possess various biological functions for the treatment of diseases such as depression, panic disorder, polycystic ovary syndrome and so on (Benjamin et al 1995;Iuorno et al 2002;McLaurin et al 2000). Furthermore, D-chiroinositol (Kawa et al 2003) and its 3-O-methyl form, D-pinitol (3-O-methyl-D-chiro-inositol; Fig. 1) (Bates et al 2000;Weeks and Albany 2003;Ostlund and …”

Section: Introductionmentioning

confidence: 99%

Rat L6 myotubes as an in vitro model system to study GLUT4-dependent glucose uptake stimulated by inositol derivatives

et al. 2007

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Some of inositol derivatives have been reported to help the action of insulin stimulating glucose uptake in skeletal muscle cells. Rat L6 myotubes were employed in an attempt to develop an in vitro model system for investigation of the possible insulin-like effect of eight inositol derivatives, namely allo-inositol, D-chiro-inositol L-chiro-inositol, epi-inositol, muco-inositol, myo-inositol, scyllo-inositol and D-pinitol. At a higher concentration of 1 mM seven inositol derivatives other than myo-inositol were able to stimulate glucose uptake, while at 0.1 mM only D-chiro-inositol, L-chiro-inositol, epiinositol and muco-inositol could induce glucose uptake, indicating their significant insulin-mimetic activity. Immunoblot analyses revealed that at least Dchiro-inositol, L-chiro-inositol, epi-inositol, mucoinositol and D-pinitol were able to induce translocation of glucose transporter 4 (GLUT4) to plasma membrane not only in L6 myotubes but also in skeletal muscles of rats ex vivo. These results demonstrated that L6 myotubes appeared efficient as an in vitro system to identify inositol derivatives exerting an insulin-like effect on muscle cells depending on the induced translocation of GLUT4.

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“…Due to containing nutritional ingredients with high biological value it is an important food source for animal and human consumption. Moreover, diets that contain buckwheat have been linked to many health-benefi cial effects such as: lowered risk of developing high cholesterol and blood pressure, less progression in stenosis and atherosclerosis, protection against breast and other hormone-dependent cancers as well as heart disease and diabetes [5][6][7][8]. The buckwheat's lipid-lowering activity is largely due to its rich supply of fl avonoids, particularly rutin.…”

Section: Introductionmentioning

confidence: 99%

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

et al. 2015

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The aim of our study was to stablish the possible alternations in fatty acid composition of brain phospholipids in rats on a standard and high-fat diet supplemented with buckwheat leaf and fl ower mixture (BLF) and subsequent possible benefi cial effects of BLF. Four months old male Wistar rats were randomly divided into fi ve experimental groups fed a standard diet, standard diet supplemented with 5% BLF, high-fat diet, high-fat diet with full-period (13 weeks) of 5% BLF supplementation and high-fat diet with partial-period (7 weeks) of 5% BLF supplementation. Gas-liquid chromatography was performed to analyze the fatty acids in hexane lipid extracts of whole rat brains.Supplementation with BLF did not induce signifi cant changes in fatty acid composition of whole brain phospholipids in rats fed the standard diet. In rats on high-fat diet concomitant (full-period) BLF supplementation increased eicosapentaenoic acid (20:5n-3, EPA), total n-6 and n-6/n-3 ratio, and decreased the percentage of oleic acid (18:1n-9) and estimated activity of Δ-9 desaturase. When BLF application was postponed (partial-period) in the case of developed hyperlipidemia, a decrease of stearic acid (18:0) accompanied with an increased estimated Δ-9 desaturase activity was observed. Regardless of BLF supplementation all high-fat diet-fed groups showed an elevated percentage of linoleic acid (18:2n-6, LA) and a reduced estimated Δ-6 desaturase activity.BLF contributes to the maintenance of stable fatty acid composition of brain phospholipids and supports normal brain function in high-fat diet rats, with more positive effects when BLF was applied before hyperlipidemia developed. This could be the mode of buckwheat health benefi cial effects on the brain.

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Buckwheat Concentrate Reduces Serum Glucose in Streptozotocin-Diabetic Rats

Cited by 140 publications

References 17 publications

Evaluation of the In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs)

Evaluation of the In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs)

Rat L6 myotubes as an in vitro model system to study GLUT4-dependent glucose uptake stimulated by inositol derivatives

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

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