2003
DOI: 10.1021/jf0302153
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Buckwheat Concentrate Reduces Serum Glucose in Streptozotocin-Diabetic Rats

Abstract: The antihyperglycemic effects of chemically synthesized d-chiro-inositol (d-CI), a component of an insulin mediator, have been demonstrated in rats. Buckwheat contains relatively high levels of d-CI: thus, it has been proposed as a source of d-CI for reducing serum glucose concentrations in diabetics. The present study evaluates the effects of a buckwheat concentrate, containing d-CI, on hyperglycemia and glucose tolerance in streptozotocin (STZ) rats. In fed STZ rats, both doses of the buckwheat concentrate (… Show more

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Cited by 142 publications
(110 citation statements)
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“…Results of animal studies showed a decreasing effect of DCI on glucose concentration in blood of streptozocin-induced rats [Kawa et al, 2003] and blood pressure, plasma triglyceride and glucose concentrations in type 2 diabetic mice [Yao et al, 2008]. Moreover, the important role of DCI glycans as a second messenger in insulin abnormal response was explained by Larner et al [2010].…”
Section: Introductionmentioning
confidence: 99%
“…Results of animal studies showed a decreasing effect of DCI on glucose concentration in blood of streptozocin-induced rats [Kawa et al, 2003] and blood pressure, plasma triglyceride and glucose concentrations in type 2 diabetic mice [Yao et al, 2008]. Moreover, the important role of DCI glycans as a second messenger in insulin abnormal response was explained by Larner et al [2010].…”
Section: Introductionmentioning
confidence: 99%
“…Some of these derivatives have been reported to possess various biological functions for the treatment of diseases such as depression, panic disorder, polycystic ovary syndrome and so on (Benjamin et al 1995;Iuorno et al 2002;McLaurin et al 2000). Furthermore, D-chiroinositol (Kawa et al 2003) and its 3-O-methyl form, D-pinitol (3-O-methyl-D-chiro-inositol; Fig. 1) (Bates et al 2000;Weeks and Albany 2003;Ostlund and …”
Section: Introductionmentioning
confidence: 99%
“…Due to containing nutritional ingredients with high biological value it is an important food source for animal and human consumption. Moreover, diets that contain buckwheat have been linked to many health-benefi cial effects such as: lowered risk of developing high cholesterol and blood pressure, less progression in stenosis and atherosclerosis, protection against breast and other hormone-dependent cancers as well as heart disease and diabetes [5][6][7][8]. The buckwheat's lipid-lowering activity is largely due to its rich supply of fl avonoids, particularly rutin.…”
Section: Introductionmentioning
confidence: 99%