By taking advantage of curved fiber paths, Variable Angle Tow (VAT) laminates increase the design space for tailoring the structural behavior of thin-walled aerospace structures. In recent years, advancements in Automated Fiber Placement (AFP) and Continuous Tow Shearing (CTS) have facilitated the manufacture of these laminates. The CTS technique holds the advantage of reducing many of the manufacturing defects characteristic of the AFP process such as fiber wrinkling, tow gaps and tow overlaps, while also allowing for tighter steering radii. On the other hand, the CTS process features added complexity due to the coupling of fiber steering angle with tow thickness. In this study, a minimummass design of a typical aircraft wing panel under end-compression subject to pre-defined manufacturing, static failure and buckling load constraints is sought. The geometric effects of the asymmetric thickness distribution of the CTS panel on the critical buckling loads, postbuckling paths and static failure behavior are captured for the first time. A hybrid optimization scheme that couples a genetic algorithm with a pattern-search algorithm is used to define a VAT laminate that reduces the mass of both square and rectangular aircraft panels by 31% compared to a baseline straight fiber design. The optimization of the fiber paths is driven by two distinct requirements, namely local and global stiffness tailoring that influence the buckling performance and static strength, respectively. Finally, the initial postbuckling behavior of the optimized designs is investigated using Koiter's perturbation approach, which reveals that postbuckling stability should be considered when optimising VAT panels manufactured by the CTS technique.