Buccal Mucosa Biomarkers in Alzheimer’s Disease

Avramouli, Antigoni; Vlamos, Panayiotis

doi:10.1007/978-3-030-32633-3_8

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…However, further studies are still required to confirm and quantify the exact correlation between SPARC/SPARC expression and the various factors that define the exercise amount, mainly the intensity and the duration. These studies should focus on numerical and quantitative correlation similar to what we have for biomarkers used in clinical practice or biomedical research [70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87] including SPARC itself, which was also suggested as a physiological and pathological biomarker [88]. Personalized medicine [89][90][91][92][93] and precision medicine [94][95][96][97][98][99][100][101] are growing areas in respect to exercise [102][103][104][105][106][107], which further highlights the potential of measuring SPARC/SPARC/Sparc expression/level in optimizing and developing medical practice.…”

Section: Figurementioning

confidence: 99%

Measuring Exercise-Induced Secreted Protein Acidic and Rich in Cysteine Expression as a Molecular Tool to Optimize Personalized Medicine

Ghanemi

Yoshioka

St‐Amand

2021

Genes

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The numerous exercise benefits for health as well as applications for diseases has lead to exercise being prescribed in many pathological conditions. Secreted protein acidic and rich in cysteine (SPARC) gene expression is stimulated by exercise and SPARC has been suggested as a molecular mediator of exercise. Therefore, we suggest using this property for personalized medicine. This can be achieved by prescribing the exercise with a pattern (duration, intensity, etc.) that corresponds to the optimum SPARC/Sparc expression. We expect this approach to optimize the exercise therapy in both the preventive and curative contexts. In the research field, measuring exercise -dependent expression of Sparc would represent a molecular tool to further optimize the selection of exercise animal models as well.

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Section: Figurementioning

confidence: 99%

Measuring Exercise-Induced Secreted Protein Acidic and Rich in Cysteine Expression as a Molecular Tool to Optimize Personalized Medicine

Ghanemi

Yoshioka

St‐Amand

2021

Genes

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“…The buccal smear is a simple test in which mucosal cells are taken from the cheek, and these cells can be used for the investigation of the cellular effects of risk factors including bacterial, fungal, and viral infections, hormonal changes, immune system changes, diabetes mellitus and iron deficiency anaemia, neoplasms, radiotherapy, chemotherapy, alcohol and smoking, as well as genetic testing 3‐11 . We postulated that the evaluation of buccal smears might be a suitable approach for investigating of the impact of prematurity on neonates.…”

Section: Introductionmentioning

confidence: 99%

Impact of preterm birth on the cellular characteristics of neonatal buccal cells

et al. 2021

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Objective To demonstrate the impact of preterm birth on the cytological, cytomorphometrical, and nuclear parameters of neonatal buccal smears. Methods This study consisted of Early Preterm Neonates (EPN; ≤34th gestational week [gw]; n = 36), Late Preterm Neonates (LPN; 34th to <37th gw; n = 46), and Term Neonates (control; ≥37th gw; n = 56). Cytological evaluation and buccal cytome assay were performed using Papanicolaou and Feulgen methods, respectively. Results Cytological evaluation demonstrated that smear background was cleaner (P < .05) and there were less macrophages in the control group (P < .001). Cyto‐morphometric analysis showed that the measurements of nuclear diameter, nuclear area, and nucleus‐to‐cytoplasm ratio were higher in the preterm (EPN and LPN) versus the control groups (P = .016, P < .001, and P < .001, respectively). We also demonstrated that staining intensity of the nucleus and cytoplasm were less intense in the EPN and LPN groups (P < .001). There was no statistically significant difference between the EPN and LPN groups for any parameters (P > .05). Buccal cytome assay showed that nuclear buds were more prevalent in term newborns compared to preterm neonates (P < .001). Conclusions Morphological and cytological properties of neonatal buccal cells are influenced by preterm birth status, and buccal smears may be used as a tool to detect biological markers of neonatal health problems.

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Relationships Between Treatment and Clinical Evaluations

Pardi

Santos

2022

Pharmacological Treatment of Alzheimer's Disease

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Buccal Mucosa Biomarkers in Alzheimer’s Disease

Cited by 5 publications

References 19 publications

Measuring Exercise-Induced Secreted Protein Acidic and Rich in Cysteine Expression as a Molecular Tool to Optimize Personalized Medicine

Measuring Exercise-Induced Secreted Protein Acidic and Rich in Cysteine Expression as a Molecular Tool to Optimize Personalized Medicine

Impact of preterm birth on the cellular characteristics of neonatal buccal cells

Relationships Between Treatment and Clinical Evaluations

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