Buccal midazolam for treatment of prolonged seizures in children

Kutlu, Nurettin Onur; Doğrul, Mehmet; Yakıncı, Cengiz; Soylu, Hanifi

doi:10.1016/s0387-7604(02)00230-9

Cited by 42 publications

(26 citation statements)

References 13 publications

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“…These administration routes achieve a more rapid onset of action and higher midazolam plasma levels with bioavailabilities up to 75% due to the avoidance of first-pass metabolism [2][3][4]. Sublingual administration has been reported to be effective in anaesthesia premedication [5,6] or in the treatment of seizures [7,8] in children. Unfortunately, a suitable midazolam formulation for intraoral administration is not freely available and the injectable solution of midazolam is commonly used for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam

Kaartama

Jarho

Savolainen³

et al. 2011

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam

Kaartama

Jarho

Savolainen³

et al. 2011

Journal of Chromatography B

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“…It was found out that buccal Midazolam was quite safe, no any significant side effects especially cardio-respiratory was observed in both groups. Both Kutlu et al [6] and Melendez et al [9] reported no adverse cardio-respiratory effects in their series of patients. There was no recurrence of seizures in the subsequent 1 hour in both the group.…”

Section: Discussionmentioning

confidence: 89%

“…Talukdar et al, [5] selected 60 cases in each group, 51 out of 60 cases (85%) seizures were aborted by buccal Midazolam and 56 out of 60 cases (93.3%) by IV diazepam. Kutlu et al [6] studied 19 patients, 84.2% seizures were aborted by buccal Midazolam. In a randomized clinical trial by Tonekaboni et al [7] 92 patients with acute seizures, ranging from 6 months to 14 years, were randomly assigned to receive either buccal Midazolam (32 cases) or I/V Diazepam (60 cases) at the emergency department of a children's hospital.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Buccal Midazolam and I.V Diazepam for Acute Treatment of Seizure in Pediatrics Age Group

Kumar¹

2017

jmscr

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“…The buccal route of BZD (between cheek and gums) studied with midazolam and lorazepam was found effective in controlling acute seizures and does not require the teeth to be parted .Buccal route is more accessible than the rectal route [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Buccal Clonazepam versus Intravenous (I/V) Midazolam for Management of Acute Breakthrough Seizure –A Randomized Controlled Trial

Kumar¹

2016

JPNC

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Objectives: To compare efficacy and safety of buccal Clonazepam with I/V Midazolam in acute seizure therapy. Methods:A prospective, open label randomized controlled trial done on children with acute breakthrough seizure in known epileptics .200 breakthrough episodes were randomized to inject able midazolam (0.2mg/kg) or buccal clonazepam (0.01mg/kg) given on even days (IV Midazolam) and odd days (buccal Clonazepam).Results: Ninety two (92.0%) seizures were controlled IV Midazolam and eighty six (86.0%) in buccal Clonazepam group. No statistical significant (p=0.175) was observed .Recurrence after initial control was 8.0% in IV Midazolam and 9.0% in buccal Clonazepam group with no statistical significant (p=0.800) .Vital monitoring parameters maintained in both groups .16.0% revealed adverse reactions 10 min post drug administration, 4.0% in the midazolam, and 12.0% in clonazepam group (p value=0.119). Adverse effects required no intervention. Conclusions MonitoringPatients were monitored for vital parameters including heart rate, respiratory rate, blood pressure, saturation for ten minutes. The side effects of each drug were compared in different age groups with different semiology and etiology of seizures. We used Clonazepam (0.25/0.50/1.00mg) mouth dissolving dispersible clonazepam tablets. Statistical AnalysisData was recorded on a predesigned proforma and it was managed on a Microsoft Excel spread sheet. Statistical analysis was performed using software between the 2 groups: IV Midazolam and Buccal clonazepam. Categorical variables were summarized by frequency .Proportions were compared by chi-square test or Fisher's exact test (where expected frequency <5). Continuous variables having a normal distribution were summarized by mean and standard deviation; for others median was used .for continuous variables, student's 't' test , Mann Whitney U test or Wilcoxon signed rank sum test were applied as appropriate .P value of <0.05 was taken as significant . ResultsThe baseline characteristics of two drug groups with respect to age, sex, etiology of seizures, types of seizure, duration of seizure,EEG,neuroimaging were statistically comparable (

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Buccal midazolam for treatment of prolonged seizures in children

Cited by 42 publications

References 13 publications

Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam

Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam

Comparative Study of Buccal Midazolam and I.V Diazepam for Acute Treatment of Seizure in Pediatrics Age Group

Buccal Clonazepam versus Intravenous (I/V) Midazolam for Management of Acute Breakthrough Seizure –A Randomized Controlled Trial

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