Bubonic Leishmaniasis: A Common Manifestation of Leishmania (Viannia) braziliensis Infection in Ceara, Brazil

Sousa, Anastácio de Queiroz; Parise, Monica E.; Pompeu, Margarida M. L.; Filho, Joao Macedo Coehlo; Vasconcelos, Isabel A. B.; Lima, José Wellington Oliveira; Oliveira, Erico G.; Vasconcelos, A. W.; David, John R.; Maguire, James H.

doi:10.4269/ajtmh.1995.53.380

Cited by 62 publications

(35 citation statements)

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“…In humans, a clinical feature of L. braziliensis infection is the development of lymphadenopathy (46,47,58). Similarly, in the murine model of L. braziliensis, dLNs from infected mice, independent of the strain used, increase in size and cell number over the course of infection, and the increase in dLN cell number does not correlate to the size or presence of the lesion at the inoculation site (10).…”

Section: Contrast Tlr9mentioning

confidence: 99%

Role of Toll-Like Receptor 9 Signaling in Experimental Leishmania braziliensis Infection

et al. 2013

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Infection with؊/؊ mice at the peak of susceptibility, suggesting that unlike observations in vitro, the parasite could induce DC activation leading to the development of Th1 cells in the absence of TLR9 expression. Taken together, these data show that TLR9 signaling is important for the early control of lesion development and parasite burden but is dispensable for the differentiation of Th1 cells secreting IFN-␥, and the high levels of this cytokine are not sufficient to control early parasite replication following L. braziliensis infection.

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Section: Contrast Tlr9mentioning

confidence: 99%

Role of Toll-Like Receptor 9 Signaling in Experimental Leishmania braziliensis Infection

et al. 2013

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“…Lymphatic spread, with nodular lymphangitis (sporotrichoid distribution) and regional lymphadenopathy are commonly seen in travelers, especially the ones infected by L. [V.] braziliensis [38,41]. In infections caused by this parasite, lymphadenopathy may even precede the appearance of cutaneous lesions, suggesting early lymphatic spread of parasites [90]. Regional lymphadenopathy has been observed in two-thirds of Brazilian patients infected with L. [V.] braziliensis.…”

Section: Clinical Manifestations 31 Cutaneous Leishmaniasismentioning

confidence: 99%

Leishmaniasis in travelers: A literature review

Mansueto

Seidita

Vitale

et al. 2014

Travel Medicine and Infectious Disease

111

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Summary Leishmaniasis is a vector-borne protozoan infection whose clinical spectrum ranges from asymptomatic infection to fatal visceral leishmaniasis. Over the last decades, an increase in imported leishmaniasis cases in developed, non-endemic countries, have been pointed-out from a review of the international literature. Among the possible causes are increasing international tourism, influx of immigrants from endemic regions and military operations. The main area for the acquisition of cutaneous leishmaniasis, especially for adventure travelers on long-term trips in highly-endemic forested areas, is represented from South America, whereas popular Mediterranean destinations are emerging as the main areas to acquire visceral variant. Leishmaniasis should be considered in the diagnostic assessment of patients presenting with a compatible clinical syndrome and a history of travel to an endemic area, even if this occurred several months or years before. Adventure travelers, researchers, military personnel, and other groups of travelers likely to be exposed to sand flies in endemic areas, should receive counseling regarding leishmaniasis and appropriate protective measures. ª

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“…preceded by an impressive enlargement of the regional lymph nodes; the term "bubonic leishmaniasis" has been coined to describe this manifestation (23). Bubonic leishmaniasis is restricted to L. braziliensis infection in Ceará; however, localized lymphadenopathy has been observed in CL patients from Bahia (2,3).…”

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DistinctLeishmania braziliensisIsolates Induce Different Paces of Chemokine Expression Patterns

et al. 2005

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Inflammatory events during Leishmania braziliensis infection in mice were investigated. Large lesions were directly correlated with the inflammatory reaction but not with parasite burden. Different L. braziliensis strains induce different paces of chemokine expression patterns, leading to diverse cell recruitment and differential inflammatory responses.Chemokines have been implicated in inflammatory responses against numerous infectious agents, including Leishmania (5,17,18,20). Leishmania braziliensis is the main agent of cutaneous leishmaniasis (CL) in Brazil; it causes single selflimited cutaneous ulcers and highly destructive mucosal leishmaniasis (10). In this study, using a murine model, we compared L. braziliensis strains isolated from two states in Brazil, namely, Ceará and Bahia, located in northeastern Brazil. CL caused by L. braziliensis is endemic in both states. In Ceará, the cutaneous lesion is accompanied and sometimes

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Bubonic Leishmaniasis: A Common Manifestation of Leishmania (Viannia) braziliensis Infection in Ceara, Brazil

Cited by 62 publications

References 0 publications

Role of Toll-Like Receptor 9 Signaling in Experimental Leishmania braziliensis Infection

Role of Toll-Like Receptor 9 Signaling in Experimental Leishmania braziliensis Infection

Leishmaniasis in travelers: A literature review

DistinctLeishmania braziliensisIsolates Induce Different Paces of Chemokine Expression Patterns

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