BTADCI Promoted One‐pot Synthesis of 14‐aryl‐14<i>H</i>‐dibenzo [a, j] Xanthenes

Pagadala, Ramakanth; Kusampally, Uppalaiah

doi:10.1002/jhet.3162

Cited by 6 publications

(5 citation statements)

References 28 publications

(16 reference statements)

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“…Pagadala and Kusampally demonstrated the solvent-free, four-component synthesis of pyrrole derivatives by using the benzyltrimethylammonium dichloroiodate (BTADCI) catalyst through a highly effective and eco-friendly strategy. [91] The reaction was found to be completed in 30 to 40 min at 80 α-bromo ketones and dialkyl acetylenedicarboxylate catalyzed by H 3 PW 12 O 40 under solvent-free conditions. [92] The reaction afforded best results when carried out at room temperature, using 0.05 mol% of the catalyst for polysubstituted pyrroles and with 0.1 mol% of the catalyst for bis-pyrroles (Scheme 37).…”

Section: Miscellaneousmentioning

confidence: 94%

See 1 more Smart Citation

Solvent‐Free Synthesis of Pyrroles: An Overview

2021

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Pyrroles are well known scaffolds having wide applications in biological and pharmaceutical field. It is a privileged heterocyclic scaffold present in many natural products, drug molecules, agrochemicals and has shown applications in material science. Solvent‐free synthesis of pyrroles became an emerging area in organic synthesis. This review focuses on the solvent‐free synthesis of pyrroles covering literature up to 2021.

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Section: Miscellaneousmentioning

confidence: 94%

“…Pagadala and Kusampally demonstrated the solvent‐free, four‐component synthesis of pyrrole derivatives by using the benzyltrimethylammonium dichloroiodate (BTADCI) catalyst through a highly effective and eco‐friendly strategy [91] . The reaction was found to be completed in 30 to 40 min at 80 °C using 50 mg catalyst.…”

Section: Miscellaneousmentioning

confidence: 99%

Solvent‐Free Synthesis of Pyrroles: An Overview

2021

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“…Pagadala et al in 2018 reported [157] for the synthesis of 14-aryl-14H-dibenzo [a, j] xanthenes using aromatic aldehydes and β-naphthol with BTADCI (Benzyltrimethylammonium dichloroiodate) as a Lewis acid catalyst in MI under solvent free conditions (Scheme 22). They established a practice with more advantages like, good yields and at a low cost of the catalyst.…”

Section: Synthesis Of Xanthenesmentioning

confidence: 99%

A Concise Review of Multicomponent Reactions Using Novel Heterogeneous Catalysts under Microwave Irradiation

Damera¹,

Pagadala

Rana

et al. 2023

Catalysts

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Multi-component reactions for the construction of heterocycles have been fascinated by microwave energy as an alternative technique of heating, owing to the advantages over traditional reflux methods. The heterogeneous catalysts contribute significantly towards recycling, harmless, easy filtration, catalyst preparation, more life span, abundance, and product yields. With novel and creative uses in organic and peptide synthesis, polymer chemistry, material sciences, nanotechnology, and biological processes, the usage of microwave energy has rapidly increased during the past 20 years. This article covers multicomponent reactions involving construction of chromenes, pyridines, pyrroles, triazoles, pyrazoles, tetrazoles, trans and cis julolidines using heterogeneous catalysts under microwave. It provides an overview of contemporary microwave-assisted heterogeneous catalytic reactions. Microwave chemistry is now an established technology with several advantages regarding reaction rate and production yield, improving energy savings as confirmed by many applications. Due to the widespread curiosity in medicinal chemistry, the heterogeneously catalysed construction of heterocycles under microwave irradiation is explored to reduce time and energy. By considering various aspects of economy, eco-friendly, and user-friendly factors, this review focuses on recent advances in the multi-component construction of heterocycles using heterogeneous catalysts under microwave irradiation. This review also discusses the benefits and limitations of reaction conditions and yields from the literature reports for the past five years.

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“…Our research interest is investigating the innovative catalysts for the construction of different biologically active heterocycles [44][45][46][47]. With this chemistry, we are mainly fascinating in producing a simpler method for the construction of multi-substituted pyridines by replacing toxic solvents and less toxic catalysts.…”

Section: Introductionmentioning

confidence: 99%

An eco‐efficient new path of mortar pestle grinding approach for the construction of methanol and ethylthio substituted pyridines with in silico studies

Edapu,

Boodida,

Pagadala

et al. 2023

Journal of Heterocyclic Chem

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A green and highly regioselective approach for the synthesis of poly‐substituted new pyridine derivatives via the Knoevenagel condensation followed by the Michael addition. The reaction involves intramolecular cyclization of easily obtainable reactants under environmentally and economically benign mortar pestle grinding technique. This method clearly proves that spatially hindered aldehydes also actively contribute to the construction of the desired pyridine derivatives with good yield (85%–96%) in about 30–40 min. This new avenue offers a number of benefits over earlier reaction approaches such as lengthy work‐up‐processes, operational difficulties and lower yields. This mortar pestle grinding technique is familiar for environmental and economical benign protocols. The druggability properties of synthesized compounds assessed using in silico studies.

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BTADCI Promoted One‐pot Synthesis of 14‐aryl‐14H‐dibenzo [a, j] Xanthenes

Cited by 6 publications

References 28 publications

Solvent‐Free Synthesis of Pyrroles: An Overview

Solvent‐Free Synthesis of Pyrroles: An Overview

A Concise Review of Multicomponent Reactions Using Novel Heterogeneous Catalysts under Microwave Irradiation

An eco‐efficient new path of mortar pestle grinding approach for the construction of methanol and ethylthio substituted pyridines with in silico studies

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