BST-104, a Water Extract ofLonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities

Bang, Byoung Wook; Park, Dongsun; Kwon, Kye Sook; Lee, Don Haeng; Jang, Myoung-Uoon; Park, Sun-Kyu; Kim, Jeom‐Yong

doi:10.1089/jmf.2018.4231

Cited by 25 publications

(25 citation statements)

References 30 publications

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“…The 15 individual symptoms of GSRS can be divided into upper and lower abdominal symptoms, and significant improvements in upper abdominal symptoms, including epigastric pain, heartburn, reflux, sensation of stomach emptiness, nausea and vomiting, rumbling, abdominal distention and eructation were observed in the test group compared to the control group. Since Flos Lonicera extracts have been reported to have gastric mucosal protective effects and to be effective in improving stomach function in animal experiments, 8 this trial demonstrated the improvement of upper abdominal symptoms in the GCWB group, which is a meaningful result. In addition, there were also improvements in lower GI symptoms, including loose stool and fecal urgency.…”

Section: Discussionmentioning

confidence: 59%

“…In addition, Flos Lonicera extracts showed excellent gastric motor improvement in the gastric emitting and GI transmission model. [7][8][9] Therefore, ingestion of GCWB104 is expected to protect and improve the function of the stomach. In addition, in reflux esophagitis model, which is related to FD, the Flos Lonicera extract improved the esophageal lesion score and histopathologic changes.…”

Section: Introductionmentioning

confidence: 99%

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The Efficacy and Safety of GCWB104 (Flos Lonicera Extract) in Functional Dyspepsia: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

et al. 2020

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Background/Aims: The Flos Lonicera extract GCWB104 has been shown to have significant protective effects against gastritis and gastric ulcers in vivo. The aim of this study was to investigate the efficacy and safety of GCWB104 in subjects with functional dyspepsia (FD). Methods: In this singlecenter, double-blind, randomized clinical trial, 92 subjects diagnosed with FD using the Rome III criteria were allocated to either the test group (300 mg of GCWB104, containing 125 mg of Flos Lonicera extract, twice daily) or the placebo group (300 mg placebo, twice daily). The total score improvement on the Gastrointestinal Symptom Rating Scale (GSRS) for individual symptoms, changes in antioxidant levels, changes in dyspepsia-related quality of life according to the Nepean Dyspepsia Index (NDI), and adverse effects were compared before and after 8 weeks of treatment. Results: The differences in total GSRS scores and score improvements after 8 weeks of treatment were significant between the GCWB104 and control groups (p=0.0452 and p=0.0486, respectively). Thirteen of 15 individual symptoms on the GSRS improved in the GCWB104 group, while six symptoms improved in the control group. In addition, statistically significant changes in rumbling, loose stool, and stool urgency were observed in the GCWB104 group. Blood 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels, known as antioxidants, showed significant reductions after 8 weeks of administration of GCWB104. There were no adverse events related to treatment with GCWB104. Conclusions: GCWB104 safely contributed to improvements in mild to moderate FD and irritable bowel syndrome symptoms. Antioxidant effects of GCWB104 were also suggested (Clinicaltrials.gov number NCT04008901).

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

The Efficacy and Safety of GCWB104 (Flos Lonicera Extract) in Functional Dyspepsia: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

et al. 2020

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“…TNF- α stimulates neutrophil infiltration, promotes IL-1 β production and epithelial cell apoptosis, inhibits the recovery of microcirculation around ulcer, and delays ulcer healing. Excessive secretion of IL-6 can activate neutrophils to form inflammatory sites, thus activating oxidative stress and lysosomal enzymes, leading to gastric mucosal damage and gastric ulcer [ 38 , 44 ]. Magnolol and honokiol, the main components of Magnolia officinalis, have been reported to have anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats

Wang

Zhang

et al. 2021

BioMed Research International

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Background. Magnolia officinalis Rehd. and Wils. is widely used in Asian countries because of its multiple pharmacological effects. This study investigated the gastroprotective effect and mechanisms of the ethanol extracts from the bark of Magnolia officinalis (MOE) against ethanol-induced gastric mucosal damage in rats. Methods. MOE was prepared by reflux extraction with 70% ethanol, and its main compounds were analyzed by UPLC-Q-Exactive Orbitrap-MS. DPPH, ABTS, and FRAP methods were used to evaluate the antioxidant capacity of MOE in vitro. The gastroprotective effects of MOE were evaluated by the area of gastric injury, H&E (hematoxylin-eosin), and PAS (periodic acid-Schiff). The mechanism was explored by measuring the levels of cytokines and protein in the NF-κB signaling pathway. Results. 30 compounds were identified from MOE, mainly including lignans and alkaloids. MOE presented a high antioxidant activity in several oxidant in vitro systems. Gastric ulcer index and histological examination showed that MOE reduced ethanol-induced gastric mucosal injury in a dose-dependent manner. MOE pretreatment significantly restored the depleted activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzymes, reduced malondialdehyde (MDA), and prostaglandin E2 (PGE2) levels in the gastric tissue in rats. In addition, MOE also inhibited the activation of nuclear factor kappa B (NF-κB) pathway and decreased the production of proinflammatory cytokines. Conclusions. The gastroprotective effect of MOE was attributed to the inhibition of oxidative stress and the NF-κB inflammatory pathway. The results provided substantial evidence that MOE could be a promising phytomedicine for gastric ulcer prevention.

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“…Polyphenol compounds, such as pyrogallol, abrogate kainic acid (KA)-induced neuronal damage through oxidative stress inhibition. Chlorogenic acid prevents gastritis through its anti-inflammatory activity [4]. Moreover, a variety of plant-derived phenolic compounds have been reported to possess distinct antioxidant and anti-inflammatory activities that contribute to their therapeutic functions [5].…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Advantages of GenoTX-407, A Combination of Extracts from Scutellaria baicalensis Root and Magnolia officinalis Bark

Yoon

Lee²,

Choi³

et al. 2020

Antioxidants

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Background: Extracts of Scutellaria baicalensis root (SBR) and Magnolia officinalis barks (MOB) possess significant antioxidant, anti-inflammatory, and antimicrobial properties; however, these also exert adverse effects such as cytotoxicity. To overcome the adverse effects, we formulated a combination of the extracts, named GenoTX-407, with SBR and MOB extracts mixed in 5:1 ratio. The antioxidant, antimicrobial, and anti-inflammatory activities of SBR and MOB extracts and GenoTX-407 were evaluated. Methods: To optimize the extraction conditions of SBR and MOB, different ethanol concentrations and extraction times and treatments of the extracts with different solvents for varying time periods were tested. Anti-inflammatory activity was assessed via NO scavenging assay and analysis of anti-inflammatory activity-related gene expression in RAW 264.7 cells. Agar disk diffusion and microdilution assays were used to determine the antimicrobial activity. Antioxidant activity was evaluated through DPPH assay and analyses of peroxidation and antioxidant-related protein expression in HeLa cells. Results: Extraction with 0% ethanol for 2 h and 1.5% phosphoric acid for 0.5 h yielded maximum SBR extracts. For MOB, 50% ethanol extraction for 2 h followed by further extraction in hexane for 0.5 h yielded the highest extracts. SBR (46.1 ± 0.9 %) and MOB (48.9 ± 1.0 %) extracts effectively inhibited NO production, and dose-dependently reduced the expression of TNF-α, iNOS, NF-κB, COX2, and IL-6. MOB and GenoTX-407 inhibited the growth of Escherichia coli, Staphylococcus aureus, Candida albicans, and Propionibacterium acnes, as evidenced in disk diffusion and microdilution assays. SBR (EC50, 107.7 µg/mL and 38.3 µg/mL), MOB (62.41 µg/mL and 72.45 µg/mL), and GenoTX-407 (7.7 µg/mL and 26.4 µg/mL) exhibited excellent antioxidant potency and could scavenge free radicals of DPPH and lipid peroxidation; additionally, SOD, CAT, HO-1, and Nrf2 expression was increased in HeLa cells. SBR showed more potent antioxidant activity than MOB. Contrastingly, MOB exhibited more potent anti-inflammatory and antimicrobial activities than SBR. Interestingly, GenoTX-407 was the most efficient in all the assays, compared with SBR and MOB. Conclusion: This study demonstrated that GenoTX-407, the combination of SBR and MOB, is a potential drug candidate exerting antioxidant and anti-inflammatory effects via the Nrf2/HO-1 and NF-κB signaling pathways.

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BST-104, a Water Extract ofLonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities

Cited by 25 publications

References 30 publications

The Efficacy and Safety of GCWB104 (<i>Flos</i> Lonicera Extract) in Functional Dyspepsia: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

The Efficacy and Safety of GCWB104 (<i>Flos</i> Lonicera Extract) in Functional Dyspepsia: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats

Pharmaceutical Advantages of GenoTX-407, A Combination of Extracts from Scutellaria baicalensis Root and Magnolia officinalis Bark

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