BSND and ATP6V1G3

Shinmura, Kazuya; Igarashi, Hisaki; Kato, Hisami; Koda, Kenji; Takahashi, Seishiro; Otsuki, Yoshiro; Yoneda, Tatsuaki; Kawanishi, Yuichi; Funai, Kazuhito; Takayama, Tadateru; Ozono, Seiichiro; Sugimura, Haruhiko

doi:10.1097/md.0000000000000989

Cited by 13 publications

(3 citation statements)

References 45 publications

(43 reference statements)

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“…STRN has multiple functional signaling complexes which are reportedly involved in the tumorigenesis of various cancers [ 45 ]. miR-342-3p additionally targets ATP6V1G3 , an integral protein-coding gene for the regulation of membrane transport, which has also been identified as an immunohistochemical marker for different cancers [ 46 ]. Lastly, PTPN4 , a PLR-associated gene, plays a role in immunity via cellular signaling and cell death prevention [ 23 , 47 ] and has been previously linked to various cancers [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma circulating microRNAs associated with blood-based immune markers: a population-based study

Leonard,

Karabegović,

Ikram

et al. 2023

Clinical and Experimental Immunology

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MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression and different immune-related pathways. There is great interest to identify miRNAs involved in immune cell development and function in order to elucidate the biological mechanisms underlying immune system, its regulation, and disease. In this study we aimed to investigate the association of circulating miRNAs with blood cell compositions and blood-based immune markers. Circulating levels of 2083 miRNAs were measured by RNA-sequencing in plasma samples of 1999 participants from the population-based Rotterdam Study collected between 2002 and 2005. Full blood count measurements were performed for absolute granulocyte, platelet, lymphocyte, monocyte, white and red blood cell counts. Multivariate analyses were performed to test the association of miRNAs with blood cell compositions and immune markers. We evaluated the overlap between predicted target genes of candidate miRNAs associated with immune markers and genes determining the blood immune response markers. First, principal component regression analysis showed that plasma levels of circulating miRNAs were significantly associated with red blood cell, granulocyte, and lymphocyte counts. Second, cross-sectional analysis identified 210 miRNAs significantly associated (P<2.82x10−5) with neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index. Further genetic look-ups showed that target genes of 7 identified miRNAs (miR-1233-3p, miR-149-3p, miR-150-5p, miR-342-3p, miR-34b-3p, miR-4644, and miR-7106-5p) were also previously linked to NLR and PLR markers. Collectively, our study suggests several circulating miRNAs that regulate the innate and adaptive immune systems, providing insight into the pathogenesis of miRNAs in immune-related diseases and paving the way for future clinical applications.

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Section: Discussionmentioning

confidence: 99%

Plasma circulating microRNAs associated with blood-based immune markers: a population-based study

Leonard,

Karabegović,

Ikram

et al. 2023

Clinical and Experimental Immunology

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“…COX17 and UQCRQ are both involved in the formation of mitochondrial respiratory chain 21 . ATP6V1G3 has also been implicated in the oxidative phosphorylation pathway and has been found to be one of the novel immunohistochemical markers for chromophobe renal cell carcinoma 22 . In addition, we also found similar changes of COX7B, COX6A2 and UQCRQ also exist in the cardiac muscle contraction pathway.…”

Section: Discussionmentioning

confidence: 99%

Changes of protein levels in human urine reflect the dysregulation of signaling pathways of chronic kidney disease and its complications

Hao

Reyes

Morris

et al. 2020

Sci Rep

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The increasing prevalence of chronic kidney disease (CKD) seriously is threatening human health and overall quality of life. The discovery of biomarkers of pathogenesis of CKD and the associated complications are very important for CDK diagnosis and treatment. In this paper, urine protein biomarkers were investigated because urine sample collection is convenient and non-invasive. We analyzed the protein concentrations in the urine of CKD patients and extracted abnormal protein signals comparing with the healthy control groups. The enriched signaling pathways that may characterize CKD pathology were identified from these proteins. We applied surface-enhanced laser desorption and ionization time of flight mass spectrometry technology to detect different protein peaks in urine samples from patients with CKD and healthy controls. We searched the proteins corresponding to protein peaks through the UniProt database and identified the signaling pathways of CKD and its complications by using the NIH DAVID database. 42 low abundance proteins and 46 high abundance proteins in the urine samples from CKD patients were found by comparing with healthy controls. Seven KEGG pathways related to CKD and its complications were identified from the regulated proteins. These pathways included chemokine signaling pathway, cytokine–cytokine receptor interaction, oxidative phosphorylation, cardiac muscle contraction, Alzheimer’s disease, Parkinson's disease, and salivary secretion. In CKD stages 2, 3, 4, and 5, five proteins showed significantly differential abundances. The differential protein signals and regulated signaling pathways will provide new insight for the pathogenesis of CKD and its complications. These altered proteins may also be used as novel biomarkers for the noninvasive and convenient diagnosis methods of CKD and its complications through urine testing in the future.

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“…Subunit G3: Subunit G3 is expressed in kidney and rat epididymis 105 , 109 . Its protein is used as a novel immunohistochemical marker for differentiating subtypes of chromophobe renal cell carcinoma (RCC) including clear cell, papillary RCCs 114 , 115 , and osteosarcoma 116 .…”

Section: Subunits Of V-atpase and Bone Diseasesmentioning

confidence: 99%

V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis

Duan¹,

Yang²,

Zhang

et al. 2018

Theranostics

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Vacuolar ATPases (V-ATPases) play a critical role in regulating extracellular acidification of osteoclasts and bone resorption. The deficiencies of subunit a3 and d2 of V-ATPases result in increased bone density in humans and mice. One of the traditional drug design strategies in treating osteoporosis is the use of subunit a3 inhibitor. Recent findings connect subunits H and G1 with decreased bone density. Given the controversial effects of ATPase subunits on bone density, there is a critical need to review the subunits of V-ATPase in osteoclasts and their functions in regulating osteoclasts and bone remodeling. In this review, we comprehensively address the following areas: information about all V-ATPase subunits and their isoforms; summary of V-ATPase subunits associated with human genetic diseases; V-ATPase subunits and osteopetrosis/osteoporosis; screening of all V-ATPase subunits variants in GEFOS data and in-house data; spectrum of V-ATPase subunits during osteoclastogenesis; direct and indirect roles of subunits of V-ATPases in osteoclasts; V-ATPase-associated signaling pathways in osteoclasts; interactions among V-ATPase subunits in osteoclasts; osteoclast-specific V-ATPase inhibitors; perspective of future inhibitors or activators targeting V-ATPase subunits in the treatment of osteoporosis.

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BSND and ATP6V1G3

Cited by 13 publications

References 45 publications

Plasma circulating microRNAs associated with blood-based immune markers: a population-based study

Plasma circulating microRNAs associated with blood-based immune markers: a population-based study

Changes of protein levels in human urine reflect the dysregulation of signaling pathways of chronic kidney disease and its complications

V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis

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