BSA-protected gold nanoclusters as fluorescent sensor for selective and sensitive detection of pyrophosphate

Liu, Jiaming; Cui, Ma-Lin; Jiang, Shu-Lian; Wang, Xinxing; Lin, Liping; Li, Jiao; Zhang, Lihong; Zheng, Zishan

doi:10.1039/c3ay00054k

Cited by 56 publications

(27 citation statements)

References 34 publications

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“…complexes for phosphate-containing metabolites were established [79]. Similarly, Liu and coworkers detected pyrophosphate in the effluent from copper plating using AuNCs protected by BSA [80]. Fig.…”

Section: Detection Of Inorganic Anionsmentioning

confidence: 89%

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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Fluorescent gold nanoclusters (AuNCs) have recently emerged as a novel kind of promising fluorescent probes for high-performance sensors and bioimaging because of their ultrasmall size (\3 nm), strong luminescence, good photostability, and excellent biocompatibility. Over the past decade, we have witnessed growing popularity of AuNCs in analytical applications and enormous efforts have been devoted to their development. In this review, we provide an update on recent advances in the development of AuNCs in terms of physicochemical properties, synthesis strategies, and bioapplications. The optical, electrochemical, catalytical, and solvatochromic properties of AuNCs are first summarized, which are followed by different ligands or template-assisted controllable synthetic methods. Afterwards functionalization of AuNCs is described in terms of ligand exchange, bioconjugation, and noncovalent interaction. We then focus on the applications of AuNCs as fluorescent probes for detection of metal ions, inorganic anions, small biomolecules, proteins, nucleic acids, drug molecules, pH, and temperature. We also summarize the usage of metal NCs in cellular and in vivo targeting and imaging. Finally, we conclude with a brief look at the future challenges and prospects of the development of AuNCs.

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Section: Detection Of Inorganic Anionsmentioning

confidence: 89%

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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“…[5][6][7] For the first time Cohn et.al purified albumin based on pH and ethanol precipitations from serum. Many researchers have tried to improve this method by several modifications.…”

Section: Discussionmentioning

confidence: 99%

Purification and Characterization of Bovine Serum Albumin Using Chromatographic Method

Balkani¹,

Shamekhi²,

Raoufinia³

et al. 2016

Adv Pharm Bull

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“…Then, the solution was kept overnight with constant stirring. 3 For the synthesis of Glu-AuNCs, glucose solution (50 mg/mL) was added to HAuCl 4 solution (10 mM/mL), and total volume was made up to 5 mL. The solution was stirred for 30 minutes followed by the addition of BSA solution.…”

Section: Auncs Synthesismentioning

confidence: 99%

Fluorescent gold nanoclusters for efficient cancer cell targeting

Purohit¹,

Singh²

2018

IJN

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Well-known surface properties of gold nanoparticles (AuNPs) offer easy surface modification with desired biomolecule, thus enabling them to be used for targeting and imaging of cancer cells/tissues. However, targeting and imaging capability come through after synthesis coating of AuNPs’ surface with targeting or imaging molecules. Attempts have been made to conjugate both imaging and targeting molecules over the AuNPs, but have seen limited success. Hence, exploiting the fluorescence properties of gold nanoclusters (AuNCs), we have synthesized glucose-coated AuNCs for exhibiting both the imaging and targeting properties. These clusters have shown rapid and selective uptake in cancerous (A549) cells when compared with bovine serum albumin-coated AuNCs.

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BSA-protected gold nanoclusters as fluorescent sensor for selective and sensitive detection of pyrophosphate

Cited by 56 publications

References 34 publications

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Purification and Characterization of Bovine Serum Albumin Using Chromatographic Method

Fluorescent gold nanoclusters for efficient cancer cell targeting

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