BSA-encapsulated cyclometalated iridium complexes as nano-photosensitizers for photodynamic therapy of tumor cells

Xu, Yao−Zhong; Wang, Xiang; Song, Kyoungsub; Du, Jun; Liu, Jinliang; Miao, Yuqing; Li, Yuhao

doi:10.1039/d1ra01740c

Cited by 16 publications

(11 citation statements)

References 42 publications

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“…Importantly, conjugation of peptides 10 and 11 carrying Met and Trp worked well to provide the products 10 a and 11 a , respectively, in excellent yields with complete suppression of side‐chain oxidation. Therefore, we postulated that these undesired oxidized products could be attributed to the generation of singlet oxygen by blue LED, [34] and therefore the employment of CFL could also initiate the radical conjugation in a mild manner ( N ‐terminal conjugation of all peptides was confirmed by tandem MS/MS analysis, see Section 5 in the Supporting Information for detailed characterization).…”

Section: Resultsmentioning

confidence: 99%

Site‐Selective Itaconation of Complex Peptides by Photoredox Catalysis

et al. 2021

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Site-selective peptide functionalization provides astraightforwardand cost-effective access to diversify peptides for biological studies.A mong many existing non-invasive peptide conjugations methodologies,p hotoredoxc atalysis has emerged as one of the powerfula pproaches for site-specific manipulation on native peptides.Herein, we report ahighly Ntermini-specific method to rapidly access itaconated peptides and their derivatives through acombination of transamination and photoredox conditions.T his strategy exploits the facile reactivity of peptidyl-dihydropyridine in the complex peptide settings,c omplementing existing approaches for bioconjugations with excellent selectivity under mild conditions.D istinct from conventional methods,t his method utilizes the highly reactive carbamoyl radical derived from ap eptidyl-dihydropyridine.I na ddition, this itaconated peptide can be further functionalizedasaMichael acceptor to access the corresponding peptide-protein conjugate.

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Section: Resultsmentioning

confidence: 99%

Site‐Selective Itaconation of Complex Peptides by Photoredox Catalysis

et al. 2021

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“…According to our previous study, iridium complexes had excellent light absorption ability and could be used in photodynamic therapy. , First, the light absorption ability of IP was evaluated. The result demonstrated that IP had adequate absorption of ultraviolet light and visible light in an aqueous solution, and the light absorption continued to about 600 nm (Figure S5).…”

Section: Resultsmentioning

confidence: 99%

Iridium Complex-Loaded Sorafenib Nanocomposites for Synergistic Chemo-photodynamic Therapy of Hepatocellular Carcinoma

Abuduwaili

Wang

Huang

et al. 2022

ACS Appl. Mater. Interfaces

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Although sorafenib, a multi-kinase inhibitor, has provided noteworthy benefits in patients with hepatocellular carcinoma (HCC), the inevitable side effects, narrow therapeutic window, and low bioavailability seriously affect its clinical application. To be clinically distinctive, innovative drugs must meet the needs of reaching tumor tissues and cause limited side effects to normal organs and tissues. Recently, photodynamic therapy, utilizing a combination of a photosensitizer and light irradiation, was selectively accumulated at the tumor site and taken up effectively via inducing apoptosis or necrosis of cancer cells. In this study, a nano-chemo-phototherapy drug was fabricated to compose an iridium-based photosensitizer combined with sorafenib (IPS) via a self-assembly process. Compared to the free iridium photosensitizer or sorafenib, the IPS exhibited significantly improved therapeutic efficacy against tumor cells because of the increased cellular uptake and the subsequent simultaneous release of sorafenib and generation of reactive oxygen species production upon 532 nm laser irradiation. To evaluate the effect of synergistic treatment, cytotoxicity detection, live/dead staining, cell proliferative and apoptotic assay, and Western blot were performed. The IPS exhibited sufficient biocompatibility by hemolysis and serum biochemical tests. Also, the results suggested that IPS significantly inhibited HCC cell proliferation and promoted cell apoptosis. More importantly, marked anti-tumor growth effects via inhibiting cell proliferation and promoting tumor cell death were observed in an orthotopic xenograft HCC model. Therefore, our newly proposed nanotheranostic agent for combined chemotherapeutic and photodynamic therapy notably improves the therapeutic effect of sorafenib and has the potential to be a new alternative option for HCC treatment.

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“…Cancer detection has become more sensitive and accurate. In the treatment of cancer, radiotherapy (RT) [ 25 , 26 ], chemotherapy [ 27 , 28 , 29 , 30 ], photodynamic therapy (PDT) [ 31 , 32 , 33 , 34 , 35 , 36 ], photothermal therapy (PTT) [ 37 , 38 , 39 ], sonodynamic therapy (SDT) [ 40 , 41 , 42 ], immunotherapy [ 43 , 44 , 45 ], starvation therapy (ST) [ 33 , 46 , 47 ], magnetothermal therapy (MHT) [ 48 , 49 ], and other therapies have also shown good anticancer effects. As a remarkable diagnostics reagent candidate, the Re element has attracted the attention of many researchers because of its unique physical and chemical properties.…”

Section: Introductionmentioning

confidence: 99%

Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy

Wang

et al. 2023

Molecules

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Rhenium (Re) is widely used in the diagnosis and treatment of cancer due to its unique physical and chemical properties. Re has more valence electrons in its outer shell, allowing it to exist in a variety of oxidation states and to form different geometric configurations with many different ligands. The luminescence properties, lipophilicity, and cytotoxicity of complexes can be adjusted by changing the ligand of Re. This article mainly reviews the development of radionuclide 188Re in radiotherapy and some innovative applications of Re as well as the different therapeutic approaches and imaging techniques used in cancer therapy. In addition, the current application and future challenges and opportunities of Re are also discussed.

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BSA-encapsulated cyclometalated iridium complexes as nano-photosensitizers for photodynamic therapy of tumor cells

Abstract: Three new iridium complexes were synthesized and fabricated with BSA to form nano-photosensitizers, which can catalyze oxygen to produce singlet oxygen to achieve photodynamic therapy of tumor cells.

Cited by 16 publications

References 42 publications

Site‐Selective Itaconation of Complex Peptides by Photoredox Catalysis

Site‐Selective Itaconation of Complex Peptides by Photoredox Catalysis

Iridium Complex-Loaded Sorafenib Nanocomposites for Synergistic Chemo-photodynamic Therapy of Hepatocellular Carcinoma

Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy

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