BSA-binding properties and anti-proliferative effects of amino acids functionalized polyoxomolybdates

Li, Chunyan; Qi, Wen; Cao, Hongqian; Zhang, Shuang; Xu, Shihan; Sun, Jiaheng; Guo, Shuanli

doi:10.1016/j.biopha.2016.01.042

Cited by 21 publications

(6 citation statements)

References 31 publications

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“…These results also demonstrated the reduction of POM aggregation due to the encapsulation. The FT-IR spectra (Fig 2C) of the POM exhibited the absorption characteristic peaks at 928, 688, 538 and 426 cm -1 , which were attributed to ν (Mo-O bridge -Mo) and ν (Mo-O terminal ) of polyoxoanion as described in the previous study [39], the corresponding peaks were exhibited in the POM@SiO 2 solid line as shown in the image (860, 617, 546, 430 cm -1 ), indicating that these compounds still retain the basic structure after encapsulated in SiO 2 . The strong absorption band at 1110 cm -1 as shown in the POM@SiO 2 line was attributed to the Si-O stretching, which further demonstrated the formation of POM@SiO 2 nanoparticles.…”

Section: Resultssupporting

confidence: 62%

“…In our previous work, the in vitro antitumor activity of K 2 Na[As III Mo 6 O 21 (O 2 CCH 2 NH 3 ) 3 ]·6H 2 O (AsMo 6 ) on lung adenocarcinoma cells (A549) was investigated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay, the results indicated that the inhibitory effect was higher than that of 5-fluorouracil (5-FU) [39]. And in the study of anti-leukemia, the compound showed low inhibitory effect on normal human umbilical vein endothelial cells (HUVEC) with an IC 50 value of 889.18 μM and a significant anticancer effect on human HL-60 and U937 leukemia cells [40].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, cytotoxicity and antitumour mechanism investigations of polyoxometalate doped silica nanospheres on breast cancer MCF-7 cells

Cao

et al. 2017

PLoS ONE

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Polyoxometalates (POMs) have shown the potential anti-bacterial, anti-viral and anti-tumor activities. In order to improve their physiological stability and antitumour activity for medical application, K2Na[AsIIIMo6O21(O2CCH2NH3)3]·6H2O doped silica nanospheres (POM@SiO2) with diameters of ~40 nm have been synthesized by the water-in-oil microemulsion method in this study. The obtained spheres were morphologically uniform nanosized and nearly monodispersed in solution. The nanoparticles had high entrapment efficiency, which was upto 46.2% by the inductively coupled plasma mass spectrometry (ICP-MS) analysis and POMs slowly released from the nanospheres both in the PH 7.4 and 5.5 phosphate buffer saline (PBS) solutions in 60 h. The in vitro MTT assays of particles on MCF-7 cell line (a human breast adenocarcinoma cell line) exhibited enhanced antitumor activity compared to that of plain polyoxometalate. The IC50 value of the POM@SiO2 nanoparticles was 40.0 μg/mL at 24 h calculated by the encapsulated POM concentration, which was much lower comparing to that of 2.0 × 104 μg/mL according to the pure POM. And the SiO2 shells showed low inhibitory effect at the corresponding concentration. Confocal images further indicated the cell morphology changes and necrosis. Flow cytometric analysis showed nanoparticles induced the apoptosis by arresting the cells in S phase and western blot analysis indicated they promoted apoptosis by inhibiting the Bcl-2 protein. Moreover, the study of interactions between human serum albumin (HSA) and the nanoparticles indicated the fluorescence quenching was static, and the nanoparticles were likely to bind to HSA and changed its conformation.

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Section: Resultssupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Synthesis, cytotoxicity and antitumour mechanism investigations of polyoxometalate doped silica nanospheres on breast cancer MCF-7 cells

Cao

et al. 2017

PLoS ONE

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“…According to the previous study, Hoechst33342 (10 μg/mL) and PI (2.5 μg/mL) were used for morphological observation [ 55 ]. HT29 cells were seeded at a density of 1 × 10 5 cells/mL in 96 well plates.…”

Section: Methodsmentioning

confidence: 99%

A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy

Chen

Zhang

et al. 2021

Molecules

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Anticancer treatment is largely affected by the hypoxic tumor microenvironment (TME), which causes the resistance of the tumor to radiotherapy. Combining radiosensitizer compounds and O2 self-enriched moieties is an emerging strategy in hypoxic-tumor treatments. Herein, we engineered GdW10@PDA-CAT (K3Na4H2GdW10O36·2H2O, GdW10, polydopamine, PDA, catalase, CAT) composites as a radiosensitizer for the TME-manipulated enhancement of radiotherapy. In the composites, Gd (Z = 64) and W (Z = 74), as the high Z elements, make X-ray gather in tumor cells, thereby enhancing DNA damage induced by radiation. CAT can convert H2O2 to O2 and H2O to enhance the X-ray effect under hypoxic TME. CAT and PDA modification enhances the biocompatibility of the composites. Our results showed that GdW10@PDA-CAT composites increased the efficiency of radiotherapy in HT29 cells in culture. This polyoxometalates and O2 self-supplement composites provide a promising radiosensitizer for the radiotherapy field.

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“…These novel POM-biomolecule hybrid compounds exert potential synergistic effects and lower cytotoxicity (Table S1) [40]. In addition, glycine-functionalized POMs (K 2 Na [As III Mo 6 O 21 (O 2 CCH 2 NH 3 ) 3 ]6H 2 O) exhibit lower toxicity to normal cells (human umbilical vein endothelial cell line, HUVECs) and better antiproliferative effects in vitro [41,42]. In addition, Wang S1) [43].…”

Section: Application Of Inorganic-organic Hybrid Pomsmentioning

confidence: 99%

“…POMs have been shown to be active against a variety of DNA and RNA viruses, including influenza viruses A and B, HBV, hepatitis C virus (HCV), herpes simplex virus, dengue virus and HIV [8,[38][39][40][41]. In addition, POMs play an important role in antibacterial activity.…”

Section: Application Of Poms For Anti-infection Therapymentioning

confidence: 99%

Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer’s disease

et al. 2022

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As shown in studies conducted in recent decades, polyoxometalates (POMs), as inorganic metal oxides, have promising biological activities, including antitumor, anti-infectious and anti-Alzheimer's activities, due to their special structures and properties. However, some side effects impede their clinical applications to a certain extent. Compared with unmodified POMs, POM-based inorganic-organic hybrids and POM-based nanocomposite structures show significantly enhanced bioactivity and reduced side effects. In this review, we introduce the biological activities of POMs and their derivatives and highlight the side effects of POMs on normal cells and organisms and their possible mechanisms of action. We then propose a development direction for overcoming their side effects. POMs are expected to constitute a new generation of inorganic metal drugs for the treatment of cancer, infectious diseases, and Alzheimer's disease.

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BSA-binding properties and anti-proliferative effects of amino acids functionalized polyoxomolybdates

Cited by 21 publications

References 31 publications

Synthesis, cytotoxicity and antitumour mechanism investigations of polyoxometalate doped silica nanospheres on breast cancer MCF-7 cells

Synthesis, cytotoxicity and antitumour mechanism investigations of polyoxometalate doped silica nanospheres on breast cancer MCF-7 cells

A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy

Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer’s disease

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