Bruton tyrosine kinase inhibitors in multiple sclerosis: evidence and expectations
Julia Krämer,
Heinz Wiendl
Abstract:Purpose of review
Despite availability of high-efficacy therapies for multiple sclerosis (MS), many patients experience significant disability worsening due to limited effects of currently available drugs on central nervous system (CNS)-compartmentalized inflammation. Bruton tyrosine kinase (BTK) is an intracellular signaling molecule involved in regulation of maturation, survival, migration, and activation of B cells and microglia, which are central players in the immunopathogenesis of progressive… Show more
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