volume 192, issue 4, P1459-1470 2014
DOI: 10.4049/jimmunol.1300125
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Rachel H. Bonami, Allison M. Sullivan, James B. Case, Hannah E. Steinberg, Kristen L. Hoek, Wasif N. Khan, Peggy L. Kendall

Abstract: Autoreactive B lymphocytes are essential for the development of T cell–mediated type 1 diabetes (T1D). Cytoplasmic Bruton’s tyrosine kinase (BTK) is a key component of B cell signaling, and its deletion in T1D-prone NOD mice significantly reduces diabetes. However, the role of BTK in the survival and function of autoreactive B cells is not clear. To evaluate the contributions of BTK, we used mice in which B cells express an anti-insulin BCR (125Tg) and promote T1D, despite being anergic. Crossing Btk deficien…

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