Bruton’s tyrosine kinase inhibition suppresses neutrophilic inflammation and restores histone deacetylase 2 expression in myeloid and structural cells in a mixed granulocytic mouse model of asthma

Nadeem, Ahmed; Alshehri, Samiyah; Al-Harbi, Naif O.; Ahmad, Sheikh F.; Albekairi, Norah A.; Alqarni, Saleh A.; Ibrahim, Khaild E; Alfardan, Ali S.; Alshamrani, Ali A.; Salman, Sami B Bin; Attia, Sabry M.

doi:10.1016/j.intimp.2023.109920

Cited by 4 publications

(1 citation statement)

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“…Corticosteroids were found to downregulate the pulmonary inflammation-related gene expressions, such as tumour necrosis factor-alpha (TNF-α), interleukin-8 (IL-8), granulocyte-macrophage colony-stimulating factor (GM-CSF), inducible nitric oxide synthase (iNOS), interleukin-1β(IL-1β) and monocyte chemoattractant protein 1 (MCP1). Decreased HDAC2 expression was related to increased inflammatory cytokines [ 80 ]. In this study, BTK inhibition by Ibrutinib reestablished HDAC2 expression level and reduced inflammatory cytokines and NFκB expression.…”

Section: Asthmamentioning

confidence: 99%

Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors

Man,

Evran

2023

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Epigenetic changes play an important role in the pathophysiology of autoimmune diseases such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis, rheumatoid arthritis, and COVID-19. There are three main classes of epigenetic alterations: post-translational modifications of histone proteins, control by non-coding RNA and DNA methylation. Since histone modifications can directly affect chromatin structure and accessibility, they can regulate gene expression levels. Abnormal expression and activity of histone deacetylases (HDACs) have been reported in immune mediated diseases. Increased acetylated levels of lysine residues have been suggested to be related to the overexpression of inflammatory genes. This review focuses on the effect of HDAC modifications on histone and non–histone proteins in autoimmune diseases. Furthermore, we discuss the potential therapeutic effect of HDAC inhibitors (HDACi) used in these diseases.

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Section: Asthmamentioning

confidence: 99%