Bruton’s tyrosine kinase inhibition ameliorated neuroinflammation during chronic white matter ischemia
Lu-Lu Xu,
Sheng Yang,
Luo-Qi Zhou
et al.
Abstract:Chronic cerebral hypoperfusion (CCH), a disease afflicting numerous individuals worldwide, is a primary cause of cognitive deficits, the pathogenesis of which remains poorly understood. Bruton's tyrosine kinase inhibition (BTKi) is considered a promising strategy to regulate inflammatory responses within the brain, a crucial process that is assumed to drive ischemic demyelination progression. However, the potential role of BTKi in CCH has not been investigated so far. In the present study, we elucidated potent… Show more
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