Brush Biopsy and Mucosal Biopsy

Bush, Andrew; Pohunek, Petr

doi:10.1164/ajrccm.162.supplement_1.maic-5

Cited by 42 publications

(28 citation statements)

References 24 publications

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“…Bronchoscopy with or without biopsy, considered to be the ''gold standard'' in the assessment of airway inflammation, is generally safe and tolerable under the hands of experienced clinicians [9][10][11] ; however, the procedure is unlikely to be widely performed in children with mild to moderate asthma because of its inherent technical difficulties and sedation requirements. IS analysis is a less invasive alternative to bronchoscopy in children with mild to moderate asthma.…”

Section: Discussionmentioning

confidence: 99%

Safety and application of induced sputum analysis in childhood asthma

Covar¹,

Spahn²,

Martin

et al. 2004

Journal of Allergy and Clinical Immunology

100

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Section: Discussionmentioning

confidence: 99%

Safety and application of induced sputum analysis in childhood asthma

Covar¹,

Spahn²,

Martin

et al. 2004

Journal of Allergy and Clinical Immunology

100

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“…It is also a well-established clinical technique for obtaining ciliated cells for the diagnosis of primary ciliary dyskinesia. Research applications for endobronchial mucosal biopsies include studies on bronchial inflammation in patients with asthma or cystic fibrosis [6,8,9,21,22]. Biopsy of superficial airway structures can be performed with a brush or forceps [22].…”

Section: Endobronchial Biopsymentioning

confidence: 99%

Flexible endoscopy of paediatric airways

Midulla¹,

Blic²,

Barbato³

et al. 2003

Eur Respir J

210

167

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Paediatric fibreoptic bronchoscopy is used for ever wider indications, and increasingly used in many contexts, including paediatric and neonatal intensive care.The report of this Task Force contains an overview on the current applications of paediatric bronchoscopy. The report discusses the facilities and equipment needed for the procedure, including the newly developed bronchoscopes which are allowing intervention even in very small children. The indications of both flexible and rigid bronchoscopes in the context of newer and smaller flexible endoscopic equipment are also considered. The care of the instruments, including disinfection and sterilisation, is fully documented. Patient management is described, including the relative merits of conscious sedation and general anaesthesia, as well as special settings for the procedure, including the needs in intensive care.Special procedures, increasingly performed bronchoscopically are described. These include bronchoalveolar lavage, endobronchial and transbronchial biopsy, laser therapy, bronchography, and endoscopic intubation and drug therapy. Finally, neonatal bronchoscopy is discussed, and the ethics of bronchoscopic procedures, including bronchoscopic research in children.Advances in instrumentation, and also improved anaesthetic techniques, allow fibreoptic bronchoscopy to be safely performed in even very small, sick infants, provided proper precautions are taken. Eur Respir J 2003; 22: 698-708.

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“…O material para análise detalhada da ultra-estrutura e função ciliar pode ser obtido por biópsia da mucosa nasal ou por escovado nasal. Este último é de mais fácil realização, tem menor custo e morbidade e permite obter material para a observação in vivo da atividade ciliar (41)(42)(43)(44)(45) . A amostra obtida do epitélio nasal deve ser encaminhada imediatamente ao laboratório para determinar a freqüência de batimento ciliar, verifi car o padrão de movimento ciliar e para a análise da ultra-estrutura ciliar por microscopia eletrô-Figura 3 -Tomografi a computadorizada em alta resolução de paciente com síndrome de Kartagener: imagens com padrão em "árvore em brotamento", brônquios espessados e ectasiados.…”

Section: Diagnóstico Laboratorialunclassified

Discinesia ciliar primária: quando o pediatra deve suspeitar e como diagnosticar?

Olm

Adde

Filho

et al. 2007

Rev. paul. pediatr.

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Síntese dos dados: A DCP é uma doença autossômica recessiva que compromete a estrutura e/ou a função ciliar e, conseqüentemente, o transporte mucociliar. As manifestações clínicas envolvem o trato respiratório superior e inferior, com infecções recorrentes do ouvido médio, seios paranasais e pulmonares, que podem evoluir para bronquiectasias. Outras manifestações incluem situs inversus totalis e infertilidade masculina. O diagnóstico deve ser suspeitado pelos pediatras em várias situações: recém-nascidos de termo com desconforto respiratório sem causa aparente; neonatos portadores de dextrocardia; lactentes com tosse persistente e/ou infecções otorrinolaringológicas de repetição, excluindo-se as imunodefi ciências e a fi brose cística; crianças com asma atípica e as com bronquiectasias sem causa defi nida. Os testes de triagem diagnóstica são os da sacarina e do óxido nítrico nasal. As avaliações do defeito ultra-estrutural e funcional exigem análise por microscopia eletrônica e da freqüência e formato da onda de batimento ciliar.Conclusões: A DCP, apesar da baixa prevalência, é pouco diagnosticada pelas difi culdades de estabelecer o diagnóstico defi nitivo do defeito ciliar devido à complexidade da investigação laboratorial e pela falta de reconhecimento da doença pelos médicos. A suspeita clínica e o diagnóstico precoce são fundamentais para reduzir a morbidade e prevenir o desenvolvimento de complicações.Palavras-chave: transtornos da motilidade ciliar; síndro-me de Kartagener; bronquiectasia; infertilidade. ABSTRACTObjective: To review primary ciliary dyskinesia (PCD) and its ultrastructural aspects, to differentiate primary from secondary ciliary defects and to describe the clinical features, screening and diagnostic laboratorial tests, and the clinical management of this disorder.Data sources: A bibliographical search was obtained from Medline, Lilacs and SciELO databases, from 1980 to 2007.Data synthesis: PCD is an autossomic recessive disorder with abnormal structure and/or function of the cilia, leading to reduced mucociliary clearance. The clinical manifestations include upper and lower respiratory tracts, with recurrent ear, sinus and lung infections that may progress to bronchiectasis. Situs inversus and male infertility are other clinical features of this disorder. PCD should be suspected by pediatricians in the following clinical situations: full term neonates with respiratory distress without apparent causes, presence of dextrocardia, infants with chronic cough and/or recurrent upper airways infections in the absence of immunodefi ciency and cystic fi brosis, children with atypical asthma and bronchiectasis without a defi nitive cause. The diagnostic screening tests are the saccharine and nasal nitric oxide tests. Functional and ultrastructural evaluations demand an electronic microscopic analysis and the observation of the frequency and the pattern of the ciliary movement.Conclusions: Although the prevalence of PCD is low, the diffi culties in establishing the diagnosis due to the complex invest...

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Brush Biopsy and Mucosal Biopsy

Cited by 42 publications

References 24 publications

Safety and application of induced sputum analysis in childhood asthma

Safety and application of induced sputum analysis in childhood asthma

Flexible endoscopy of paediatric airways

Discinesia ciliar primária: quando o pediatra deve suspeitar e como diagnosticar?

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